【作者】 朱容；

【导师】 曹阳； 王江；

【作者基本信息】 海南大学 ， 材料物理与化学， 2010， 硕士

【摘要】 磷酸钙骨水泥(calcium phosphate cement, CPC)由于其在化学组成上与骨组织的无机成分相同,同时具有优良的生物性能,即骨传导性和骨诱导性,得到了国内外广泛的关注和研究。本文制备得到贝塔磷酸三钙(β-Ca3(PO4)2,β-TCP),将其作为骨水泥的固相成分,以壳聚糖、柠檬酸、聚乙烯醇混合溶液作为液相,采用正交试验,从凝固时间和抗压强度两方面确定了液相的最佳配比,制备可满足临床需要的磷酸钙骨水泥。同时,本文设计制备了具有荧光效果的Eu3+掺杂β-TCP材料,利用铕的荧光特性,示踪β-TCP中钙离子在骨修复过程中的作用、迁移过程。通过XRD分析表明,Eu3+掺杂β-TCP主晶相仍保持其原有的六方结构,通过计算得到其晶格常数发生变化,证明Eu3+进入β-TCP晶胞中；同时,在高分辨率透射电镜中也得到证实；在荧光显微镜下可看到明显的红色荧光,有利于其在骨诱导性的研究中进行示踪；同时,利用电感耦合等离子质谱跟踪检测了Eu离子,一定程度上示踪了Ca2+动向,从而为进一步研究骨诱导效应的具体过程和机理提供基础。更多还原

【Abstract】 Nowadays, CPC is attractive in a broad range of special interest, due to its chemical component is similar to the mineral phase of hard tissue, and high biocompatibility--osteoinductivity and osteoconduction.In this paper, self-madeβ-TCP powder used for solid phase of CPC. While the liquid phases were chitosan, citric acid and polyvinyl alcohol. The design orthogonal was tested to determine the best ratio of the system from the coagulation time and compressive strength of the CPC.Then,β-TCP doped europium were prepared which have fluorescence effect, take advantage of fluorescence characteristics of europium to tracing the role and migration process of calcium in the bone repair.XRD analysis represents thatβ-TCP containing europium have the same structure withβ-TCP. However, the changed lattice constants obtained by calculating shows that Eu3+ doping into the P-TCP unit cell which was also proved by HRTEM image. The fluoresence microscope demonstrate the complex show clear red luminescence, which are helpful to tracing studies in osteoinductive. ICP-MS analysis shows that, the contents of Eu3+ in the saline solution trace the Ca2+, it is beneficial in tracing study of osteoinductivity.更多还原