【作者】 杜佩珊；

【导师】 鹿育萨；

【作者基本信息】 山西医科大学 ， 心血管内科学， 2010， 硕士

【摘要】 目的观察正常高值血压患者血清高敏C反应蛋白(hs-CRP)与尿微量白蛋白(ALB)的水平,分析二者之间的相关性。方法选择正常高值血压110例,对照组为同期体检健康者87例,用ELISA法分别测定血清hs-CRP、ALB;空腹血糖(FBG)、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL)、体重指数(BMI)。结果正常高值血压组血清hs-CRP、ALB水平显著高于对照组(P<0.05)；且存在明显性别差异,男性显著高于女性(P<0.05)。hs-CRP与ALB呈正相关(P<0.01, r=0.47), TC、TG、BMI、FBG、LDL均与二者呈正相关(P<0.05)。结论正常高值血压患者血清hs-CRP、ALB水平明显升高,提示机体已存在炎症反应。TC、TG、BMI、FBG、LDL均是炎症反应的相关因素,雌激素可能对女性心血管系统有保护作用。更多还原

【Abstract】 ObjectiveThis study was performed to investigate the changes of serum high-sensitivity C-reactive protein level and Albuminuria level in patients with prehypertension and to investigate the relationship between hs-CRP and ALB.MethodsTotal FBG,TC,TG,BMI,LDL were measured in 110 patients with prehypertension and 87 normal controls. Serum hs-CRP and ALB concentration was measured by ELISA.ResultPrehypertension of serum hs-CRP, urinary albumin concentration was significantly higher than that; and high male than female (P<0.05). hs-CRP, ALB with TC, TG, BMI, FBG, LDL was a positive correlation (All P<0.05).ConclusionThe serum hs-CRP and ALB level are increased obviously in the patient with prehypertension, prehypertension has an inflammation reaction.The elevated levels of TC, TG, FBG, LDL and BMI all correlate with inflammation. Estrogen on the female cardiovascular system may have protective effects.更多还原