【作者】 古思嘉；

【导师】 刘奇志；

【作者基本信息】 大连医科大学 ， 内科学， 2010， 硕士

【摘要】 目的：观察左旋卡尼汀治疗慢性心力衰竭患者的临床疗效。方法：选择慢性心力衰竭患者60例,随机分为常规治疗组(对照组,30例)和左旋卡尼汀组(治疗组,30例),对照组给予利尿剂、血管紧张素转换酶抑制剂(ACEI)或者血管紧张素受体拮抗剂(ARB)、β受体阻滞剂、洋地黄制剂以及硝酸酯类药物治疗,治疗组在此基础上加用左旋卡尼汀2.0g静脉滴注,1天/次,连续用药连用7-10天。观察治疗前后患者的心功能。结果：两组患者临床疗效间差异有显著性意义(P<0.05)；心功能检查方面,与治疗前比较左室射血分数(LVEF)、左室短轴缩短率(LVFS)、左室舒张末内径(LVEDD)明显改善。治疗组患者治疗后的生活质量有明显改善,与治疗前比较差异有显著意义(P<0.05)。结论：左旋卡尼汀可以辅助性治疗慢性心力衰竭,提高心功能,尤其提高左室收缩功能以及改善生活质量。更多还原

【Abstract】 Objective:To evaluate the efficacy of L-carnitine on the heart function in chronic heart failure patients.Methods:Sixty patients with chronic heart failure were divided into conventional therapy group (control group,30 patients) and L-carnitine therapy group (therapy group,30 patients). The control group patients were given basic treatment with digoxin, diuretics, angiotensin converting enzyme inhibitor(ACEI) or angiotensinⅡreceptor blocker (ARB), andβ2blocker; the therapy group were given L-carnitine 2g/d for 7 to 10days in addition to the basic treatment.Heart function was observed before and after L-carnitine treatment.Results:Clinical efficacy between the two groups were statistically differences(P<0.05). Inspection of cardiac function, left ventricular ejection fraction(LVEF),left ventricular fractional shortening(LVFS),left ventricular end diastolic diameter(LVEDD) of patients increased signi-ficantly in L-carnitine group. In the quality of Life, the therapy group after treatment, which compared with before treatment, wassignificantly improvement (P<0.05).Conclusion:L-carnitine can be used as adjuvant treatment with chronic heart failure, and it can increase cardiac function,especially in left ventricular function. At the same time improving the quality of life.更多还原