五苓散加味治疗糖尿病黄斑水肿的临床观察

【作者】 郝美玲；

【导师】 韦企平；

【作者基本信息】 北京中医药大学 ， 中西医结合临床， 2010， 硕士

【摘要】 目的：探讨五苓散加味治疗糖尿病黄斑水肿的临床疗效方法：将我院眼科门诊2009年7月1日～2009年12月30日收治的糖尿病黄斑水肿的病例共17例32只眼,随机分为单纯中药组(A组10例19只眼),球周注射TA组(B组7例13只眼)。两组患者中若有激光治疗适应症者,激光光凝术后一周随机纳入A、B组。A、B两组均观察一个月。疗效评价指标：采用视力(BCVA)和经第4代OCT测量的四项指标：黄斑中心区直径lmm范围的厚度(Central Subfield Thickness, CST)、黄斑中心区直径6mm的平均厚度(Average Thickness)、黄斑水肿区的最高厚度和黄斑中心区直径6mm的总体积(Volume)四项指标,并观察治疗后可能出现的并发症。结果：两组的BCVA、CST、平均厚度、黄斑水肿区的最高厚度和黄斑区总体积均较治疗前有显著统计学差异(P<0.05)。而两组疗效差别无显著统计学差异(P>0.05)。两组无一例出现不良反应。结论：五苓散加味治疗DME短期内有一定疗效,但长期疗效尚待观察。中药治疗与球周注射TA治疗DME,短期观察二者疗效无统计学上的差别更多还原

【Abstract】 Objective:To investigate the clinical efficacy of Wuling Powder Modified on the treatment of diabetic macular edema.Methods:Between July 1,2009～December 30,2009,32 eyes of 17 patients were admitted to cases of diabetic macular edema in our eye clinic of Dongfang Hospital. They were randomly divided into Chinese Medicine Croup (A group of 10 cases of 19 eyes) and peribulbar injection of Triamcinolone acetonide (TA) group (B group of seven cases of 13 eyes). If any patient in two groups needs laser treatment on DR, after one week after laser photocoagulation, he may be admitted into the observation group. Both groups were observed for one month. Efficancy evaluation:best corrected visual acuity (BCVA) and the following four indicators measured by the Cirrus HD-OCT:Central Subfield Thickness (CST),Average thickness, the maximum thickness of macular edema and the volume of macular area,which diameter range of 6mm. Besides, the complications were evaluated after treatment.Results:Both oftwo groups’BCVA, CST, average thickness, maximum thickness of macular edema and volume show a significant statistical difference than those before treatment (P<0.05). Efficacy difference between two groups shows no significant statistical difference (P> 0.05). None of the two groups’elevation of intraocular pressure and other complications occurred.Conclusion:The treatment of Wuling Powder Modified on the DME is valid after short-term observation. Still the long-term efficancy remains to be seen. Efficacy shows no statistical difference after the short-term observation, compared with the treatment of TA on DME through peribulbar injection.更多还原