加味旋覆代赭汤对肿瘤患者上消化道重建术后生活质量影响的研究

【作者】 黄如敬；

【导师】 王笑民；

【作者基本信息】 北京中医药大学 ， 中西医结合临床， 2010， 硕士

【摘要】 目的：观察加味旋覆代赭汤对肿瘤患者上消化道重建术后生活质量的影响。方法：观察30例在辨证论治处方中应用加味旋覆代赭汤治疗的上消化道重建术后的肿瘤患者。治疗前后采集病史,检测体重、血常规、肝肾功等项。以QLQ-C30量表中文版及功能性消化不良辨证分型及评分量表为基础调查表,比较用药前后临床症状及实验检测指标的变化情况。结果：本研究共收集病例36份,有效病例30份。其中男性21例,女性9例；门诊患者20例,病房患者10例；年龄为18～75岁,其中30岁以下0例,31-50岁8例,51-70岁16例,71-75岁6例,以51～70岁(53.3%)为主；入组期间进行化疗者8例,未进行化疗者22例；入组期间合并其他用药者13例,未合并用药者17例。胃癌术后25例,食道癌术后4例,壶腹癌术后1例。结果显示性别、年龄、病程长短、有无转移部位、入组期间有无进行放化疗及入组期间有无合并其它用药等因素在加味旋覆代赭汤治疗期间未有差异性影响。中医证型以肝郁脾虚证(43.3%)为主,其次为脾虚痰湿证(20%)及饮食积滞证(16.7%),肝郁气滞证(13.3%)及寒热错杂证(7%)较少。加味旋覆代赭汤治疗前后,患者生活质量无明显改善,在总体健康状况/生存质量、功能、症状等方面无提高。结论：上消化道重建术后肿瘤患者应用加味旋覆代赭汤对生活质量的提高无明显效果。更多还原

【Abstract】 Objective:observe the influence of Modified Xuan Fu Dai zhe Tang treating the cancer patients’quality of life after upper digestive tract reconstruction。Methods:observe 30 cancer patients who are treated by Modified Xuan Fu Dai zhe Tang after the treatment of upper digestive tract reconstruction。Before and after the treatment, collect the medical record, test weight, b lood routine examination, liver and kidney function tests, and other items。Compare clinical symptoms and every test results pre-and post-the treatment in the base of QLQ-C30 scales and functional dyspepsia Syndrome Type and rating scale.Results:This study collected 36 cases,30 cases were effective。Including 21 males and 9 females; 20 cases of outpatients and 10 cases of inpatients. The range of Age is from 18 to 75 years, including 0 case of less than 30 years old,8 cases of 31-50 years old,16 cases of 51-70 years old, 6 cases of 71-75 years old, which mainly in the group of 51 to 70 years old(53.3%); there are 8 patients with chemotherapy while 22 cases with no chemotherapy during the study period; 13 patients Combined with other drugs while 17 cases without combined drugs。There are 25 Gastric cancer patients,4 esophageal cancer patients and 1 Ampullary carcinoma patient, who were all suffered the Surgery。The results show that the factors such as gender, age, duration of disease, Metastasis, with or without chemotherapy or other drugs have no effect to the quality of life。TCM Syndrome Types mainly include liver depression and spleen deficiency (43.3%), followed by the spleen with phlegm (20%) and diet Indigestion card (16.7%), liver qi stagnation (13.3%) and fever and chills mixed evidence (7%) less. Modified Xuan Fu Dai zhe Tang has no influention to the quality of life in patients who had have the Upper digestive tract reconstruction in overall health status/quality of life, function, symptoms and so on.Conclusion:Modified Xuan Fu Dai zhe Tang before and after treatment, the quality of life in patients with no significant improvement in overall health status/quality of life, function, symptoms and so on and so on radio.更多还原