益气养阴解郁法治疗糖尿病伴发抑郁症的临床研究

【作者】 王玉霞；

【导师】 高彦彬；

【作者基本信息】 北京中医药大学 ， 中医内科学， 2010， 硕士

【摘要】 糖尿病伴发抑郁症发病率在逐年增高,糖尿病患者中抑郁症的患病率高达33%,且平均每个患者5年中有4.2次复发,每年有0.8次发作。抑郁症的发生不但加重糖尿病的病情,廷缓疾病的康复,而且可显著影响个体的心身健康、社会交往、职业能力及躯体活动。由于糖尿病伴发抑郁症的高发病率,高复发率,糖尿病伴发抑郁症的防治备受医学界关注。本论文分为文献综述和临床研究两部分。文献综述部分由中医药治疗糖尿病伴发抑郁症研究进展和糖尿病伴发抑郁症研究进展两部分组成。中医药治疗糖尿病伴发抑郁症研究进展着重从病名、病因病机、中医辨证论治、专方治疗等方面概述近10年来中医药治疗的进展。糖尿病伴发抑郁症研究进展回顾了近年来国内外对本病的基础和临床研究进展。主要从机理研究和治疗方面进行了论述。其发病机理,至今尚未完全阐明。目前临床治疗药物有8种,但总体疗效并不理想,尤其是病情严重的患者。临床研究部分观察了中医益气养阴解郁法对糖尿病伴发抑郁症的临床疗效。将符合标准的糖尿病合并抑郁症患者60例,随机分为治疗组(30例)和对照组(30例),在基础治疗的同时,治疗组予具有益气养阴解郁法的中药汤剂治疗；对照组予口服氟西汀(百忧解)治疗。对病人的HAMD积分、症候积分、及症状积分进行了观察。结果：治疗组的总有效率为83.33%,对照组的总有效率为66.67%。经Ridit检验显示治疗组明显优于对照组(P<0.05)。结果显示益气养阴解郁中药对糖尿病伴发抑郁症患者的神疲乏力、少气懒言、口干咽燥、忧愁善感、烦躁易怒、胁胀等症状改善明显。治疗过程中未见明显的不良反应。结论：益气养阴解郁法治疗糖尿病伴发抑郁症安全有效,中医中药治疗糖尿病伴发抑郁症有着明显优势。更多还原

【Abstract】 The incidence of diabetes with depression increase year by year. Diabetes prevalence rate of depression up to 33%, and the average 5 years in patients with recurrence of 4.2,0.8 times each episode. Not only increases the incidence of depression, diabetes, disease, delay the rehabilitation of the disease, but also can significantly affect the individual’s physical and mental health, social contacts, professional competence and physical activity. Because diabetes high incidence of depression, high recurrence rate, diabetes prevention and treatment of depression been concerned about the medical profession.The thesis consists two parts:the literature review and the clinical research.Chinese literature review parts consist of Chinese medicine treatment of diabetes with depression research and the progress of diabetic with depression of two parts. First, Chinese medicine treatment of diabetes with depression research focus from the name of disease, pathogenesis, syndrome differentiation, specifically outlined in the Treatment of areas in the past 10 years. Secondly, we review recent advances on the basis of this disease and clinical research. Mainly from the mechanism and treatment are discussed. Its pathogenesis, has not yet fully understood. There are 8 clinical therapy currently, but the overall effect, especially in patients with severe effect is not satisfactory.Traditional Chinese medicine clinical research part of the observation method Yiqiyangyin Jieyu Diabetes clinical depression. Will meet the standards of diabetes patients with depression 60 cases were randomly divided into treatment group (30 cases) and control group (30 cases), while in the basic treatment, treatment group with Yiqiyangyin Stasis Decoction of treatment; the control group to fluoxetine (Prozac) treatment. Effect on the patient’s medicine, HAMD rating scale score, symptom scores, and symptom scores were observed. Results:The total effective rate was 83.33% in the control group, the total effective rate was 66.67%. After inspection by the treatment group by Ridit higher than the control group sex (P<0.05). The results also show Yiqiyangyin Jieyu medicine on diabetes mellitus patients with depression Shenpi fatigue, less gas lazy words, dry mouth and throat, sentimental sadness, irritability, threatening inflation and other symptoms were improved. And no obvious side effects. Conclusion:Relieving Depression Yiqiyangyin treatment of diabetes and depression medicine is safe and effective traditional Chinese medicine treatment of diabetes and depression have a distinct advantage.更多还原