【作者】 厉胜；

【导师】 廖泉；

【作者基本信息】 中国协和医科大学 ， 外科学， 2010， 硕士

【摘要】 目的：探讨胰腺恶性神经内分泌肿瘤的影像学检查方法及其手术方式的选择。方法：回顾性总结北京协和医院2003.1-2009.12收治的胰腺恶性神经内分泌肿瘤病例32份,所有病人均行B超、CT检查,根据需要进一步行超声内镜、PET、生长抑素受体显像等检查。根据病人肿瘤的分布及疾病特点选择手术方式。收集所有病例的一般资料、术后病理结果以及预后情况,评估它的影像学检查方法及手术方式的选择。结果：胰腺原发灶的单独切除后功能性神经内分泌肿瘤病人内分泌诱导的临床综合症状全部获得了缓解或部分缓解,非功能性神经内分泌肿瘤病人的临床症状获得缓解；功能性胰腺神经内分泌肿瘤肝转移灶行减瘤术可减轻其内分泌诱导的临床综合症状。结论：胰腺恶性神经内分泌肿瘤应积极行手术治疗。肝转移灶手术切除结合介入栓塞、射频消融等综合治疗可以缓解临床症状,使病人获得临床受益。更多还原

【Abstract】 Imaging features and surgical treatment of malignant pancreatic neuroendocrine tumorObjective:To investigate the imaging methods and surgical options for the malignant pancreatic neuroendocrine tumor.Methods:We retrospectively summarized the clinic data of 32 patients with malignant pancreatic neuroendocrine tumors who admitted in PeKing Union Medical College Hospital between 2003.1 and 2009.12. All patients underwent BUS, CT examination, or further endoscopic ultrasound, PET, somatostatin receptor imaging, etc. The surgical methods were selected according to locatin of tumors and disease characteristics. The general information, postoperative pathology results, prognosis, imaging methods and surgical options were also collected.Results:The functional neuroendocrine tumors induced clinical endocrine syndrome of all patients and the clinical symptoms of non-functional neuroendocrine tumors were eased or partial remissioned after pancreatic resection. The endocrine-induced clinical syndrome of functional pancreatic neuroendocrine tumors metastasised in liver can be reduced by cytoreductive surgery.Conclusion:Malignant pancreatic neuroendocrine tumors should be actively treated surgically. Liver metastases resection combined with embolization or radiofrequency ablation can relieve clinic symptoms, so that patients can get clinical benefit.更多还原