【作者】 许胜杰；

【导师】 邱向红；

【作者基本信息】 广州中医药大学 ， 中西医结合临床， 2010， 硕士

【摘要】 研究目的以脾肾相关理论为指导,通过临床疗效的对比分析,证实健脾补肾法比单纯的健脾法对延髓肌受累症状明显(如吞咽苦难、饮水呛咳等)的ⅡB型重症肌无力患者有更好的疗效。研究方法1.根据ⅡB型重症肌无力患者的临床表现特点及辅助检查设计统一的“ⅡB型重症肌无力患者治疗前后症状调查表”,对每一位纳入对象进行登记、评分。将纳入研究的ⅡB型重症肌无力患者随机分为治疗组(健脾补肾组)和对照组(单纯健脾组),分别应用不同的治法方药治疗观察1个月,然后再次对纳入对象评分。2.全部临床资料采用SPSS 11.0 for Windows统计软件包进行统计分析。计量资料以均数±标准差(x±s)表示。符合正态分布者采用配对t检验,非正态分布者采用秩和检验(Rank sum test)。显著性检验均值α=0.05,若P<0.05,则差异有显著性意义。研究结果1.本课题总病例数共60例,其中治疗组(健脾补肾组)和对照组(单纯健脾组)各30例。分别应用健脾补肾法和单纯健脾法治疗,结果有效率前者为86.7%,后者为80.0%。2.经统计分析,两组有效率之间有显著性差异(P<0.05)。3.症状评分分析：肾虚相关症状：两组间治疗前的差异无显著意义(P>0.05),而两组治疗前后改善程度的差异有显著意义(P<0.05)。脾虚相关症状：两组间治疗前的差异以及两组治疗前后改善程度的差异均无显著意义(P>0.05)。研究结论通过临床疗效对比分析发现,健脾补肾法较单纯健脾法治疗延髓肌受累症状明显的ⅡB型重症肌无力效果更好,值得进一步研究。更多还原

【Abstract】 Objective:To spleen and kidney-related theory as theory basis, through comparative analysis of clinical efficacy, confirming the method of invigorating spleen and kidney than simply nourishing the spleen on bulbar muscular involvement symptoms (such as swallowing suffering, water choke) in patients withⅡB myasthenia gravis has a better effect. Methods:1. IIB myasthenia gravis patients have the different clinical characteristics. In accordance with the requirements of this subject, design a table which is used to collect the information about the patients who have been divided two groups. The patients in the different treatment are given to different medications a month.Then the information is collected again.2. SPSS11.0 statistical software package proceeds were used for statistics analysis.Results:1. The total number of cases is 60, including treatment group (invigorating spleen and kidney) and control group (nourishing spleen) 30 cases each. The patients in the different treatment are given to different medications, resulting in the efficiency of the former was 86.7%, the latter was 80.0%.2. There was significant in the efficiency of two groups (P<0.05).3. Symptom score analysis.Kidney-related symptoms:the difference between the two groups before and after treatment was no significant (P>0.05), while the two groups in the degree of improvement was significant (P<0.05).Spleen-related symptoms:the difference between the two groups before treatment after treatment and the degree of improvement showed no significant difference (P>0.05). Conclusion:Through comparative analysis of clinical efficacy, confirming the method of invigorating spleen and kidney than simply nourishing the spleen in patients withⅡB myasthenia gravis has a better effect. It is worthy of further study.更多还原