【作者】 陈思；

【导师】 孙田杰；

【作者基本信息】 中国医科大学 ， 护理学， 2010， 硕士

【摘要】 研究目的1、评估化疗期乳腺癌患者在不同化疗周期的疾病不确定感的水平。2、明确不同化疗周期乳腺癌患者疾病不确定感的影响因素。研究方法采取目的抽样的方法,选取2009年1月-2009年10月中国医科大学乳腺外科需要进行乳腺癌术后6个周期的化疗患者,于第一次化疗前、第三次化疗前及第六次化疗前应用疾病不确定感量表对其疾病不确定感水平进行测评。采用自行设计的一般状况调查表收集患者的社会人口学资料和疾病相关资料；应用SPSS16.0进行数据处理,采用均数、标准差、百分比等来描述患者的一般资料；用方差分析来比较患者三个化疗期间不同时间点的疾病不确定感水平,进一步用LSD检验法进行多样本均数的多重比较；用多元逐步回归分析来探讨乳腺癌患者疾病不确定感的影响因素。结果1、本研究有60例研究对象,全部完成了调查问卷的填写。结果显示,化疗期乳腺癌患者疾病不确定感水平处于中等水平,在化疗周期三个不同时间点的的得分差异均有统计学意义(P<0.05)。进一步分析显示,患者的疾病不确定感的不明确和不可预测在第一次化疗前与第六次化疗前均有差异。2、疾病不确定感影响因素分析显示,化疗副反应种类、学历、年龄、家庭人均月收入和医疗费用支付方式是影响疾病不确定感重要的因素,分别在化疗期三个不同的时间点对疾病不确定感总分及其四个维度产生不同的影响。结论1、化疗期乳腺癌患者三个不同时间点存在中等程度的疾病不确定感。2、在化疗期三个不同的时间点,患者的疾病不确定感主要来源于疾病不确定感的不明确和不可预测。3、化疗期乳腺癌患者三个不同时间点的影响因素也不同。更多还原

【Abstract】 Objective1、To investigate the levels of uncertainty in breast cancer patients with chemotherapy at different times.2、To evaluate the effecting factors of uncertainty in illness.MethodsBy purpose of sampling,60 breast cancer patients in breast cancer surgical department of the first affiliated hospital of china medical university were recruited in the study. The levels of uncertainty in breast cancer patients undergoing total six chemotherapy cycles were assessed with Chinese version MUIS-A(Mishel Uncertainty in illness Scale-Adult) before the first, third and sixth chemotherapy. Individual characteristics and related data of illness were collected with self-designed questionnaire.The data were caculated by SPSS 16.0. Individual characteristics of patients were described by mean±SD or percentage. The levels of uncertainty prior to three chemotherapy were evaluated by ANOVA(analysis of variance), and mean multiple comparision among groups further caculated by LSD. The effecting factors of uncertainty in illness were explored with stedwise hierarchical multiple regression.Results1、The 60 participants who were recruited into the study, all that completed the questionnaire. The results show that the level of illness uncertainty of breast cancer women undergoing chemotherapy was middle at different time points. The scores of the three time points showed significant difference(P<0.05). Further analysis showed that patients with uncertainty in illness, the uncertainty arose mainly from unpredictability and ambiguity at the first and sixth chemotherapy.2、Uncertainty factors analysis showed that type of chemotherapy side effects, education, age, family income and payment of medical expenses affect the uncertainty of disease in the chemotherapy at three different time points. Uncertainty of disease score and its four dimensions have different impacts.Conclusions1、Chemotherapy in patients with breast cancer in three different points in time there ismoderate uncertainty in illness.2、During the three time points during chemotherapy, the uncertainty arose mainly from unpredictability and ambiguity.3、Chemotherapy in breast cancer patients have different factors at different time points.更多还原