【作者】 宋英杰；

【导师】 吴云飞；

【作者基本信息】 中国医科大学 ， 外科学， 2010， 硕士

【摘要】 目的：探讨皮肤病合并恶性肿瘤的临床特点、诊断、治疗和预后因素。方法：回顾性分析5例皮肤病合并恶性肿瘤的临床资料并结合文献复习。结果：2例乳腺癌合并皮肌炎患者均行乳癌改良根治术,病理为浸润性导管癌(淋巴结14/21转移)和原位癌(淋巴结0/17伴4枚癌结节),因术后不能耐受静脉化疗,予内分泌治疗。1例乳腺淋巴瘤合并皮肌炎者行乳房肿物切除术及腋窝淋巴结活检术,术后因肺间质病2个月死亡；1例获得性鱼鳞病伴发乳腺癌者行改良根治术,病理为浸润性导管癌(淋巴结10/25转移),给予T方案化疗6周期及内分泌治疗；1例红皮病伴发淋巴瘤者给予CHOP方案化疗1周期,因肺转移死亡。其余患者随访至今未见复发和转移。结论：恶性肿瘤有时会以皮肤病变为首发表现,临床容易漏诊和误诊,对于患有皮肌炎、获得性鱼鳞病、红皮病的患者有必要进行恶性肿瘤的筛查。更多还原

【Abstract】 Objective:To explore the clinical characteristics,diagnosis、treatment and prognostic of malignant tumor and dermatomyositis.Methods:The clinical data of 5 patients with malignant tumor and dermatomyositis were analyzed retrospectively and discussed with literature. Results:Two patients received modified radical mastectomy,invasive ductal carcinoma (lymph node metastasis 14/21) and carcinoma in situ (lymph node metastasis 0/17,cancer node 4),because they could not afford systemic chemotherapy after surgery,only received endocrine therapy.One patient received breast tumor excision and axillary lymph node biopsy,however,died of interstitial lung disease at two months after operation; 1 cases of acquired ichthyosis associated with breast cancer underwent modified radical mastectomy,pathology of infiltrating ductal carcinoma (10/25 lymph node metastasis), patients receiving chemotherapy for six cycles and T program endocrine therapy; 1 cases of erythroderma associated with lymphoma,CHOP chemotherapy were given one cycle,due to death of lung metastasis.Conclusion:Sometimes,dermatosis as the initial manifestation of malignant tumor,clinical easily missed diagnosis and misdiagnosis,so malignant tumor selection is necessary to patients suffering from dermatomyositis, acquired ichthyosis, erythroderma patients.更多还原