节点文献
骨形成蛋白-2/7在腰椎融合中效果的META分析
Systematic Review of Effect of Bone Morphogenetic Proteins-2/7 in Lumbar Fusion
【作者】 刘欣；
【导师】 朱悦；
【作者基本信息】 中国医科大学 ， 骨科学， 2010， 硕士
【摘要】 目的应用骨形成蛋白(BMP-2及BMP-7)进行腰椎融合与单纯应用传统植骨(包括自体骨、异体骨及人工骨)材料进行腰椎融合的效果进行系统评价。方法计算机及手工检索相关的中英文杂志,检索相关文献的参考文献。收集所有关于应用骨形成蛋白进行腰椎融合与应用传统植骨方法进行腰椎融合术后临床效果比较的随机及类随机对照研究,并评价纳入研究的方法学质量。统计软件应用Cochrane协作网提供的RevMan5.0.18。结果共纳入符合标准的相关文献14篇。Meta分析表明：1.在腰椎前路及后路的椎间融合和后外侧融合中应用BMP-2比传统植骨融合方式有更好的融合率；在后外侧融合中应用BMP-7与传统植骨融合方式相比融合率没有差别；2.与传统植骨融合方式相比,应用BMP-2／7进行腰椎融合的术后疗效没有差别。结论应用BMP-2进行腰椎融合可提高术后融合率,但与疗效无关。
【Abstract】 ObjectiveTo evaluate the effectiveness of bone morphogenetic proteins-2/7(BMP-2/7) versus traditional standard treatment (include autograft, allograft and artificial material graft) in lumbar fusion.MethodsRandomized and quasi-randomized controlled trials were identified from Pubmed, EBSCO, Springer and CBM(Chinese Biological and Medical database).We handsearch the relative reference, Chinese and English orthopaedic journals. The data of the articles were evaluated by Jadad form. RevMan 5.0.18 were used to analysis the data.ResultsFourteen randomized or quasi-randomized controlled trials were included. The combined results showed that compare with the traditional standard treatment, using the BMP-2/7 in lumbar fusion proved:1. the higher fusion rate in the cases which used BMP-2 in anterior or posterior lumbar interbody fusion and posterolateral lumbar fusion, but using BMP-7 could not lead to higher fusion rate in posterolateral lumbar fusion,2. There is no better outcome when using BMP-2/7.ConclusionCompared with traditional standard treatment, the outcome of fusion with BMP-2/7 is similar but with higher fusion rate when using BMP-2 in lumbar fusion.