【作者】 桂小红；

【导师】 罗巍；

【作者基本信息】 浙江大学 ， 临床医学， 2010， 硕士

【摘要】 目的：评定39项帕金森病调查表(the 39-item Parkinson’s Disease Questionnaire, PDQ-39)中文版在中国大陆应用的信度和效度。方法：由确诊的71位帕金森病患者自己完成PDQ-39量表和健康测量量表SF36(The Medical Outcomes Study 36-Item Short-Form Health Survey,SF-36)的评定,并让这些病人一周后再次填写PDQ-39量表。采用统一帕金森病评定量表(the United Parkinson’s Disease Rating Scale,UPDRS)和Hoehn and Yahr分级量表(H&Y)对所有参与者进行评估。量表信度采用克朗巴哈系数(Cronbach’sα)和内在等级相关系数(intra-class correlation coefficients,ICC)评价,效度采用PDQ-39与SF-36,UPDRS量表中相关子量表之间的相关系数来验证。结果：PDQ-39量表中文版被证实具有较好的信度(Cronbach’sα:0.84-0.88,ICC：0.56-0.82)以及令人满意的集合效度与区分效度(条目-维度相关系数：0.33-0.88,区分效度的平均成功率：77.56%)。PDQ-39与UPDRS量表中相关子量表之间的相关系数(0.44-0.68)以及PDQ-39与SF-36量表中相关子量表之间的相关系数(-0.46--0.69)均表明PDQ-39量表具有较好的聚合效度(p<0.01)。除了耻辱、认知与身体不适三个维度之外,PDQ-39量表的其他维度均能明确区分出H&Y分级不同病情阶段的患者。结论：尽管我们的研究提示PDQ-39某些子量表(如耻辱、认知、社会支持)可能需要进一步改进与完善,但我们这项研究表明PDQ-39量表中文版在中国大陆的应用具有较好的信度和效度。更多还原

【Abstract】 Objective:To assess the Mainland Chinese version of the 39-item Parkinson’s Disease Questionnaire (PDQ-39).Methods:Seventy-one patients with Parkinson’s Disease (PD) completed the PDQ-39 and the Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36) by themselves. All the participants were retested with the PDQ-39 a week later. The United Parkinson’s Disease Rating Scale (UPDRS) and the Hoehn and Yahr scale (H&Y) were used to evaluate the patients. Reliability was assessed by Cronbach’s a and intra-class correlation coefficients (ICC). Validity was examined in terms of agreement with SF-36, UPDRS and H&Y scales.Results:The Mainland Chinese version of the PDQ-39 demonstrated acceptable reliability (Cronbach’sα=0.84-0.88; ICC:0.56-0.82). Item-total correlations (0.33-0.88) and scaling success rates (mean:77.56%) indicated satisfactory convergent and discriminant validity of the PDQ-39 items. The correlations between related constructs of the PDQ-39 and UPDRS (r=0.44-0.68), and between those of the PDQ-39 and SF-36 (r=-0.46--0.69) were all statistically significant (p<0.01). Except for stigma, cognitions and bodily discomfort, all other dimensions of the PDQ-39 significantly discriminated patients at different H&Y stages indicated by the H&Y scale.Conclusions:lthough our observations indicate that some problematic subscales of this version of the PDQ-39 could be improved upon, this study suggests acceptable reliability and validity of the Mainland Chinese version of the PDQ-39.更多还原