【作者】 向未；

【导师】 谭万初；

【作者基本信息】 成都中医药大学 ， 中医内科学， 2009， 硕士

【摘要】 目的：观察大半夏汤治疗化疗呕吐的疗效并探讨其止呕机理。方法：①采用家鸽腹腔注射DDP法诱发呕吐模型,随机分为5组(DDP组、阳性胃复安对照组、大半夏汤高、中、低剂量组),每组10只,另选体重、月龄相当的10只家鸽作为空白对照组。治疗7天后,观察家鸽呕吐频率、呕吐物量及一般情况,用酶联免疫吸附试验(ELISA)法检测家鸽胃内组织Cajal间质细胞(ICC)的含量。②临床研究采用自身前后对照方法,观察大半夏汤治疗30例化疗呕吐患者,连续用药14天,对治疗前后患者的恶心、呕吐分级及身体一般状况Karuafsky积分进行统计分析,总结评定疗效。结果：①大半夏汤对化疗致呕家鸽有较好的止呕作用。大半夏汤高、中、低剂量组、阳性胃复安对照组家鸽胃组织中Cajal间质细胞(ICC)的含量均较DDP组增加(P<0.05),且与剂量相关。②治疗前后患者恶心、呕吐症状比较均有统计学意义；大半夏汤改善患者身体一般状况有效率为83.3%；恶心呕吐症状完全缓解3例,部分缓解20例,总有效率为73.3%。结论：大半夏汤对化疗呕吐有较好疗效,止呕的机制可能与升高胃内组织中Cajal间质细胞(ICC)水平、恢复胃起博区的ICC结构及功能有关。更多还原

【Abstract】 Objective:To observe curative effect of DaBanXia Decoction(DBXD) in treating the chemotherapy-induced nausea and vomiting and explore the antiemetic mechanism.Methods:1.Using the pigeon-induced vomiting model by Intraperitoneal injection of DDP were randomly divided into 5 groups:DDP group,positive control group high-dose of DBXD group,Middle -dose of DBXD group and Low-dose of DBXD group, each group had 10 pigeons.Another 10 weight and month considerable pigeons were selected as control group.The frequency of pigeons’vomiting, vomitus volume and the general situation,content of Cajal interstitial cells (ICC) in pigeon gastric tissue byenzyme- linked immunosorbent assay (ELISA) Detection were observed after 7 days treatment.2.30 chemotherapy-induced nausea and vomiting patients with DaBanXia Decoction treatment for 14 days were clinically observed.Patients with nausea, vomiting grading and general body condition Karuafsky points before and after treatment were statistical analysis, summarized assessment of efficacy.Resaults:1.DaBanXia Decoction had a better antiemetic effect with pigeon that chemotherapy-induced nausea and vomiting. DaBanXia Decocti6n high, medium and low dose group and the positive control group content of ICC in pigeon gastric tissue increased and related with the dose,compared with DPP group, P< 0.05.2.Compared with nausea and vomiting symptoms in patients before and after reatmen were statistically significant. After the DaBanXia Decoction treatment general body condition improvement efficient was 83.3%;3 cases symptoms of nausea and vomiting were complete relieved and 20 cases symptoms of nausea and vomiting were partially relieved, total effective rate was 73.3%.Conclusion:DaBanXia Decoction had better efficacy with chemotherapy-induced nausea and vomiting, the possible mechanism of antiemetic may be associated with increasing gastric tissue Cajal interstitial cells (ICC) level, restoring gastricpacemaker area of the structure and function of ICC.更多还原