【作者】 边鲜丽；

【导师】 王建湘；

【作者基本信息】 湖南中医药大学 ， 中医外科学， 2007， 硕士

【摘要】 目的:观察抗银药浴剂治疗寻常型血热型银屑病的临床疗效,分析其对血液流变学及血浆内皮素的影响。方法:纳入105例寻常型血热型银屑病患者,随机分为抗银药浴组(治疗组)和糠浴组(对照组),观察临床疗效。并检测用药前后血液流变学及血浆内皮素的变化。结果1.两组患者经治疗后症状、体征均有不同程度改善。治疗组总有效率为90.9%,对照组总有效率为76.0%,治疗组优于对照组,两组间差异具有显著统计学意义(P＜0.01)。2.寻常型血热型银屑病各组与健康组血液流变学及血浆内皮素相比,差异有显著性。3.两组血液流变学多项指标和血浆内皮素在治疗后均有下降,但治疗组比对照组下降程度更大,有显著性差异。结论:抗银药浴剂对寻常型血热型银屑病的疗效较好;2.血液流变学多项指标与血浆内皮素在寻常型血热型银屑病患者中都有不同程度增高,其在银屑病发病中有重要意义。3.抗银药浴剂能相对显著的降低血液流变学多项指标与血浆内皮素,血液流变学及血浆内皮素的变化能反映寻常型银屑病病情程度的变化,可作为抗银药浴剂治疗寻常型血热型银屑病疗效观察的一个客观指标,是抗银药浴剂药理作用机制之一。更多还原

【Abstract】 Objective:We want to observe the therapeutic effect on treatment of KangYin Bathe Lotion and effect on hemorheology and ET.Methords:Randomly divided 105 cases of patients with Psoriasis Vulgaris of Blood-heat Type into treatment group(with KangYin Bathe Lotion),control group(with bran Bathe Lotion),observed clinic effect,detected the change of hemorheology and ET before and after treatment.Results:There are different content improvement in symptom and physical sign after intervention in two groups.Total effect rate is 90.9 percent in treatment group,76.0 percent in control group.The effect rate of treatment group is better than the control group’s.It is significant in statistics between two group(P＜0.01),Conclusions:1.It was better to treat Psoriasis Vulgaris of Blood-heat Type with KangYin Bathe Lotion.2.Most index in hemorheology and ET were raise in varying degree,wich was important to Psoriasis Vulgaris. 3.KangYin Bathe Lotion could decrease most index in hemorheology and ET relatively significantly.Hemorheology and ET could reflet the change of pathogenetic condition of Psoriasis Vulgaris,as an objective index of the efficacy for KangYin Bathe Lotion treated Psoriasis Vulgaris,wich is one pharmaco-mechanism for it.更多还原