【作者】 廖海燕；

【导师】 谭长连；

【作者基本信息】 中南大学 ， 医学影像， 2009， 硕士

【摘要】 目的:采用功能磁共振技术(functional magnetic resonance imaging,fMRI),探讨精神分裂症患者一级亲属是否存在静息状态的脑功能异常以及脑功能异常区域定位。方法:选择13例符合第四版美国精神障碍与统计手册(Diagnosticand statistical manual,fourth edition DSM-IV)诊断标准的精神分裂症患者的同胞为研究组,13例与精神分裂症患者同胞年龄、性别、受教育年限相匹配的正常人为正常对照组,两组均进行静息状态的血氧水平依赖(blood oxygen level dependent,BOLD)的脑功能成像。采用统计参数图(statistical parametric mapping,SPM2)经头部运动检测、去基线漂移、空间标准化以及高斯平滑后用局部一致(regional homogeneity,ReHo)方法处理fMRI数据。为比较精神分裂症一级亲属和正常对照在静息状态下的脑功能差异,对以ReHo方法得到的两组KCC(Kendall coefficient concordance)图像中相应位置的体素逐个进行两样本t检验。结果:与正常人相比,精神分裂症一级亲属在静息状态下脑的BOLD信号的ReHo普遍降低(P＜0.005)。ReHo降低的脑区有双侧额中回、颞中回、扣带回、小脑扁桃体;左侧额下回、顶下小叶、前额叶中部背侧皮层;右侧额上回及前额叶中部背侧皮层。ReHo增高的脑区有右侧楔前叶及颞上回。结论:精神分裂症一级亲属在静息状态下存在脑功能异常。静息状态下血氧依赖水平的fMRI将成为精神分裂症的重要研究手段。更多还原

【Abstract】 Objective: To explore whether and where abnormal brain activity exists in the first-degree relatives of schizophrenia during resting state by using functional magnetic resonance imaging ;and the mapping of abnormal area in fMRI of the relatives of schizophrenia.Methods: 13 first degree relatives of schizophrenia(study group) and 13 healthy controls(control group)were enrolled in this study. They all underwent fMRI in resting state. The newly published ReHo approach was applied for fMRI data analysis after realignment, registration, normalization and smooth in SPM2. For exploring the difference of fMRI between the schizophrenic and controls, a two-sample t test was performed on the individual in a voxel by voxel manner. Resulted statistical map was set a combined threshold of p<0.005 and the number of voxel>5.Results: Compared to control group, the first-degree relatives of schizophrenia showed decreased ReHo of BOLD signal in resting brain compared with control subjects (P<0.005) . The decreased ReHo was distributed over bilateral medial frontal, middle temporal, cingulate gyrus and cerebellar tonsil; the left inferior frontal gyrus, inferior parietal lobule and dorsolateral prefrontal cortex; the right superior frontal gyrus and dorsolateral prefrontal cortex. The increased ReHo was distributed in the right precuneus and superior temporal gyrus. Conclusions:The resting state fMRI study showed that abnormal brain activity in the first-degree relatives of schizophrenia might exist in resting state. BOLD-fMRI will be an important research means in schizophasia.更多还原