【作者】 肖云钊；

【导师】 刘紫庭；

【作者基本信息】 中南大学 ， 泌尿外科学， 2009， 硕士

【摘要】 目的:观察a受体阻滞剂对梗阻后兔肾盂压力的影响。方法:本实验将48只家兔随机分组,人为造成家兔输尿管梗阻,实验组（A组）给予a受体阻滞剂,对照组（B组）予以生理盐水,检测各组服药前后的肾盂压力改变。结果:对照组肾盂压力从8.60±1.77cmH₂O升高到17.92±2.58cmH₂O,梗阻组肾盂压力从8.42±1.50cmH₂O升高到17.92±2.56cmH₂O,两组自身前后比较具有统计学意义（P＜0.05）。梗阻组肾盂压力从17.92±2.56cmH₂O下降到14.56±3.30cmH₂O,差异有显著性（P＜0.01）。结论:1.输尿管梗阻后兔肾盂压力明显上升。2.a受体阻滞剂可减轻输尿管梗阻后兔肾盂的压力,可能与a受体阻滞剂松弛输尿管下段、膀胱三角区及膀胱颈平滑肌有关。更多还原

【Abstract】 Objiective:To observe the impact of a-adrenoreceptor blocker of rabbit renal pelvis pressure of obstruction.Methods:Carry 48 rabbits through experiment with randomized, make the urinary system block of rabbits’ in man-made,the experimental group(A group) feed through Terazosin Hydrochloride Tablets,and the control group(B group) feed through saline.Detect the changes of the renal pelvis pressure of each group rabbits before and after medication.Results:Control group,renal pelvis pressure increased from 8.60±1.77cmH2O to 17.92±2.58cmH2O,while obstruction group pelvis pressure increased from 8.42±1.50cmH2o to 17.92±2.56cmH2O,Comparison of the two groups before and after their were statistical significance(P＜0.05 ).The obstruction group pelvis pressure dropped from 17.92±2.56cmH2O to 14.56±3.30cmH2O,There was a significant difference(P＜0.01).Conclutions:1 Ureteral obstruction significantly increased the pressure of the rabbit renal pelvis.2.A-adrenoreceptor blocker can reduce the pressure of the rabbit renal pelvis on rabbit after ureteral obstruction,which may be associated with a lower relaxation ureter and bladder trigone and bladder neck smooth muscle-related under the effection of a-adrenoreceptor blocker.更多还原