【作者】 钟良瑞；

【导师】 涂彩霞；

【作者基本信息】 大连医科大学 ， 皮肤性病学， 2009， 硕士

【摘要】 目的:总结和分析白塞病的临床及治疗特点,以加强对白塞病的认识,提高临床诊治水平。方法:分析43例白塞病患者初发部位、临床表现、实验室和组织病理检查、治疗及疗效的情况。结果:本组白塞病以女性、慢性型多见,好发于青壮年。9例急性型发病诱因以上呼吸道感染为主,应注意病毒或细菌感染在急性型发病机制中的作用。表现为口腔溃疡有41例(95.35%),以其为首发症状的有37例(90.24%)。表现为生殖器溃疡有19例(44.19%),眼部损害有15例(34.88%),针刺反应阳性有20例(46.51%),皮肤损害以结节性红斑最多见17例(39.53%),关节受累11例(25.58%)。除此外,白塞病尚可累及消化道和神经系统等。实验室检查无特异性,病理检查符合血管炎改变。应用糖皮质激素、免疫抑制剂或中西医结合治疗,病情得到控制或缓解。结论:白塞病是累及全身多系统器官以血管炎改变为基础的免疫性疾病。诊断主要依靠临床症状,反复口腔溃疡是诊断白塞病的主要依据,针刺反应有辅助诊断意义。白塞病治疗目前尚无统一方法,糖皮质激素、免疫抑制剂、中西医结合治疗能很好地控制病情。更多还原

【Abstract】 Objective: To improve the diagnosis and treatment of Behcet’s disease via analyzing its clinical manifestations and treatment outcomes.Methods: The clinical manifestations,laboratory,pathological results, treatments and curative effects were analyzed in 43 patients with Behcet’s disease.Results: Most cases in this group were middle-aged females with chronic onset.Nine patients with acute onset were predisposed by upper respiretory infection.The role of virus or bacterial infection in the pathogenesis of acute stage should be emphasized.Oral ulcer was found in 41 cases (95.35%),which was the initial clinical sign in 37 cases (90.24%).Genital ulcer was found in 19 cases (44.19%),while ocular involvement in 15 cases (34.88%).20 cases (46.51%) suffered form needling reaction.Erythema nodosum were seen in 17 cases (39.53%) and arthritis were seen in 11 cases (25.58%).Some patients were complicated with alimentary tract and neurologic manifestations.Laboratory examinations were no specificity. Histopathological examinations of skin revea- led the changes in vasculitis. All of the patients had idea response to glucocor- ticoids,immunosuppressive agents or combined therapies.Conclusion: Behcet’s disease is an autoimmunologic disorder charact- erized with vasculitis which can involve multisysterm.The diagnose depen- ds mainly on clinical symptoms.Repeated oral ulcer is the main diagnosis evidence,and needling reaction assist the diagnose.At present, although a consensus on treatment of Behcet’s disease has not been reached,it is wide- ly accepted that glucocorticoids and immunosuppressive agents have good curative effects.更多还原