【作者】 张付玉；

【导师】 单伟光； 占扎君；

【作者基本信息】 浙江工业大学 ， 药物化学， 2009， 硕士

【摘要】 中国有着非常丰富的中草药资源,对中国中草药的化学成分进行系统的研究,以期发现具有重要活性的先导化合物是创新药物发现的重要途径之一,同时可以为中草药的进一步开发和利用提供科学依据。本论文利用正相硅胶、反相材料(RP-18,MCI)以及凝胶(Toyopearl HW-40C)对两种药用植物半边旗(Pteris semipinnata L.)和千金子(Euphorbia lathyris L.)的化学成份进行了系统详细的研究,共分离得到20个化合物。通过现代分析手段,如紫外光谱(UV)、红外光谱(IR)、质谱(MS)及核磁共振技术(NMR),尤其是二维核磁(~1H-~1HCOSY,HSQC,HMBC,NOESY)技术对化合物结构进行了鉴定,确定了19个化合物的结构,其中5个为新化合物。从半边旗中分离得到13个化合物,鉴定了其中的12个,其中5个新化合物,包括1个新1H-茚-1-酮型倍半萜,1个新对映贝壳杉烷型二萜,1个新1H-茚-1-酮型倍半萜苷,1个新半日花烷型二萜苷和1个新1H-茚-1-醇型倍半萜。从千金子中分离坚定了7个化合物,包括单油酸甘油酯,巨大戟二萜醇,七叶内酯及4个续随子型二萜,其中单油酸甘油酯首次从千金子中分离出。更多还原

【Abstract】 China has abundant Chinese traditional and herbal drugs resources. Investigation on the chemical and biological constituents of Chinese traditional and herbal drugs is important for the discovery of new drug leads and the endowment of scientific background for Chinese traditional and herbal drugs.In this paper,the chemical and biological constituents of two plant species,Pteris semipinnata L.and Euphorbia lathyris L.were carried out.Twenty compounds were totally isolated,and the structures of nineteen compounds were established by utilization spectral methods such as IR,UV,MS,NMR,especially 2D NMR techniques(~1H-~1H COSY, HSQC,HMBC,NOESY).Among them,five are structurally new compounds. Thirteen compounds were isolated from Pteris semipinnata L.,the structures of twelve compounds were established,in which there were five new compounds,including one new 1-H-indan-1-one-type sesquiterpenoid, one new ent-kaurane-type diterpenoid,one new 1-H-indan-1-one-type sesquiterpene glucoside,one new labdane-type diterpene glucoside and one new 1-H-indan-1-ol-type sesquiterpenoid.Seven compounds were isolated from Euphorbia lathyris L.,including glycerol monooleate,ingenol,aesculetin,and four lathyrane-type diterpenoids.Among them,glycerol monooleate is obtained from Euphorbia lathyris L.for the first time.更多还原