【作者】 李军伟；

【导师】 王树荣；

【作者基本信息】 山东中医药大学 ， 中西医结合基础， 2009， 硕士

【摘要】 目的:基于“证-药效-药性”模式,通过观察归肺经的黄芪、党参、桔梗,不归肺经的丹参对肺气虚动物模型肺表面活性物质和分泌性免疫球蛋白含量影响的可能性差异,探讨中药归经现象。方法:以肺气虚大鼠模型为研究对象,观察黄芪、党参、桔梗、丹参对“肺主宣发肃降”的指标—肺表面活性物质水平、肺主卫气指标—分泌性免疫球蛋白的影响,以及肺朝百脉的指标—血清NO水平的影响,探讨中药不同功效与特定的物质基础的相关性。结果:桔梗对“肺主宣发肃降”的指标—肺表面活性物质影响较大;黄芪、党参对分泌性免疫球蛋白的作用明显优于桔梗;丹参在对肺朝百脉的指标—血清NO含量的影响上占优势,但与黄芪、党参差异无显著性;基于统计结果和粘膜免疫的考虑,肺与大肠相表里与粘膜的主要免疫分子SIgA有一定的相关性。说明中药不同的功效对应肺内不同的物质基础。丹参在肺朝百脉的功能意义上也归肺经。结论:基于“证-药效-药性”模式,依据中药功效的深入理解结合现代肺生理研究探讨归经的物质基础,是一种切实可行的思路和方法。更多还原

【Abstract】 Objective: According to the syndromes-effect-nature model, we discuss the theory of meridian tropism of the Chinese medicine by observing the possibility of differences of the impact Chinese medicine Astragalus root, Pilose asiabell root, Platycodon Root which enter the lung meridian and Pilose asiabell root which does not enter the lung meridian on the content of Pulmonary surfactant and secretory immunoglobulin A of lung Qi-deficiency model.Method: Studying in rats of Lung Qi deficiency, we observer the affection of Astragalus root, Pilose asiabell root, Platycodon Root, Platycodon Root on the level of pulmonary surfactant which is the index of“lung controlling dispersing outward and inwards”and secretory immunoglobulin which is the index of“lung controlling Qi”,and the level of NO which is the index of“convergence of vessels in the lung”,discussing different efficacy of traditional Chinese medicine with specific relevance to the material basis.Result: Platycodon Root make a quite obvious affection on the index of“lung controlling dispersing outward and inwards”pulmonary surfactant;Astragalus root and Pilose asiabell root affect secretory immunoglobulin more obvious than Platycodon Root; Platycodon Root is on the dominant in the index of“lung controlling dispersing outward and inwards”NO content ,but it has no difference from Pilose asiabell root and Astragalus root; Based on consideration of statistical results and mucosal immunity ,”the lung is internally and externally related to the large intestine”has some relevance to the major immune molecules SIgA. These describe that different effectiveness of the Chinese medicine corresponding to different substances in the lung. Platycodon Root pertain to the meridian of lung on the functional significance of“lung controlling dispersing outward and inwards”.Conclusion: Based on the syndromes-effect-nature model, according to the deep understanding of Chinese medicine,combining modern study of lung physiology ,we probe the basic material of Meridian Tropism is an idea and method practical and feasible.更多还原