【作者】 陈从从；

【导师】 刘静君；

【作者基本信息】 山东中医药大学 ， 中医妇科学， 2009， 硕士

【摘要】 目的:探讨止痛调经方治疗寒凝血瘀型原发性痛经（Primary dysmenorrhea,PD）的临床疗效及作用机制。方法:将50例属于寒凝血瘀型原发性痛经的患者随机分为止痛调经方组（治疗组）和少腹逐瘀胶囊组（对照组）各25例,比较两组用药前后的中医症状疗效、疼痛疗效、盆腔血流阻力、搏动指数、雌激素（E₂）、孕激素（P）等相关指标的变化。结果:在中医证候疗效方面,治疗组总有效率为96%,对照组总有效率为72%,两组比较有显著性差异（P＜0.01）。在疼痛疗效方面,治疗组明显优于对照组,两组比较有统计学意义（P＜0.05）。治疗组疗后盆腔血流阻力指数、搏动指数疗效优于对照组（P＜0.05）,治疗后治疗组较对照组E₂含量下降明显（P＜0.05）,P含量上升,两组比较差异有显著性（P＜0.01）。结论:止痛调经方能够有效改善痛经患者的临床症状和体征,提高临床疗效;能改善盆腔血循环,减少子宫动脉血流阻力,调节卵巢激素水平,改善内环境。更多还原

【Abstract】 Objective: To investigate clinical efficacy and mechanism of action the treatment of blood stasis type caused by cold accumulation Primary Dysmenorrheal.Methods: 50 cases of the patients with blood stasis type caused by cold accumulation primary dysmenorrhea were randomly divided into Pain-relieving and regulating menstruation formula. treatment group （treatment group） 25 cases and shaofuzhuyu Capsule （control group） of the 25 cases.Before and after medication,the therapeutic effects on PD ,TCM symdroms, pelvic blood flow resistance index changes in related indicators,and the E₂、P were compared. Results: In the aspect of comprehensive curative effect the TCM symdroms of the Treatment group was 96%, the control group was72%, the two groups which were compared with had significant difference （P <0.05）. in the aspect of pain Syndromes’effect, the treatment group was significantly better than the control group （P <0.05）. The two groups which were compared with had significant difference （P <0.05） in the aspect of RI、PI curative effect,the treatment group was significantly better than the control group （P <0.05）. The E₂ level of treatment group obviously decreased（P <0.05）.The P level of treatment group obviously increased（P <0.01）.Conclusion: Pain-relieving and regulating menstruation formula can effectively improve the clinical symptoms and signs of the PD’patients, improve the clinical efficacy; improve pelvic blood circulation.reduce uterine artery resistance and the homeostatic equilibrium of organism and consolidate curative effect更多还原