【作者】 韦晓丹；

【导师】 卫玉彩；

【作者基本信息】 河北医科大学 ， 眼科学， 2009， 硕士

【摘要】 后发性白内障是现代白内障囊外摘除术后最常见的并发症。白内障摘除联合后房型人工晶体植入是现代白内障治疗的常用的手术方法,能给患者带来较好的视力和生活质量,然而术后的主要并发症后囊膜混浊(posterior capsular opacification, PCO)是影响术后视力的主要原因。现代白内障手术保留部分前囊膜和完整的后囊膜,术中虽然尽可能清除晶体上皮细胞,但晶体上皮细胞仍部分残留。其后囊下混浊发生的机制主要与残留晶体上皮细胞迁移、增殖和转分化有关。现在开展的治疗主要是激光后囊膜切开。现就近些年关于后发性白内障的发生机制、晶体设计、手术方式、药物及基因预防和治疗后发性白内障的研究进展作一综述。更多还原

【Abstract】 Posterior Capsule Opacification (PCO) is the most common complication of cataract surgery.At present, the only means of treating cataract is by surgical intervention, and this initially restores high visual quality.Unfortunately, PCO develops in a significant proportion of patients to such an extent that a secondary loss of vision occurs. A modern cataract operation generates a capsular bag, which comprises a proportion of the anterior and the entire posterior capsule.However, on the remaining anterior capsule, lens epithelial cells stubbornly reside despite enduring the rigours of surgical trauma.The mechanism of posterior capsule opacification is mainly related with migration ,proliferation and transdifferentiation of remain crystal epithelial cells. At present ,the main therapy aimming to it is laser incision of posterior capsule.This article reviewed the biological mechanisms driving PCO progression and discuss the influence of IOL design, surgical techniques and putative drug therapies in regulating the rate and severity of PCO.更多还原