【作者】 徐婷；

【导师】 蔡尚郎；

【作者基本信息】 青岛大学 ， 内科学， 2009， 硕士

【摘要】 目的研究肢体缺血预适应(LIP)对大鼠缺血再灌后心脏损伤的影响。方法采用反复捆绑后肢造成缺血预适应的方法,观察其对心肌缺血再灌后心脏血流动力学、ST-段的影响、对心肌缺血再灌后梗死面积和形态学改变的影响,对心肌酶CK-MB和cTn-Ⅰ的影响以及对抗氧化物酶的影响。结果与缺血再灌组比较,预适应对心肌缺血再灌后HR和MAP的影响不具显著性差异,但是LIP能明显推迟心律失常出现的时间,缩短持续时间,降低心律失常的发生率,降低ST段的抬高幅度,并且能减少心肌梗死面积,降低心肌细胞的损害,减少心肌酶的漏出并能提高SOD的活性。结论LIP对心肌损伤具有保护作用。更多还原

【Abstract】 Objective:To observe the effect of limb ischemic preconditioning(LIP) on the myocardial ischemia-reperfusion(I/R) injury in rats.Method:Using ischemic preconditioning in hind limb model was to investigate the effect on myocardial physiology,ST-segment,the effect on myocardial infarct size and morphologic change,the effect on the enzyme of CK-MB and cTn-I after myocardial I/R.Results:Compared with I/R,the difference Was not significant on HR and MAP,but the apperanc time of VA was delayed and the duration time was shorten,the incidence rate of VA was decreased,the elevation of ST-segment was decreased,the myocardial infarct size was reduced,the myocardial injury was attenuated,the leakage of CK-MB and cTn-I were decreased and the activity of SOD was increased after pretreated with LIP. Conclusion:LIP could protect against myocardial injury.更多还原