【作者】 胡云辉；

【导师】 马依彤；

【作者基本信息】 新疆医科大学 ， 内科学， 2009， 硕士

【摘要】 目的:新疆地区汉族动脉僵硬度的流行病学调查及探讨新疆地区汉族踝臂脉搏波速度的危险因素。方法:通过分层抽样收集新疆地区乌鲁木齐市、克拉玛依市、伊犁州周边县市乡镇汉族居民共1130例。使用日本Colin公司生产的动脉僵硬度早期检测仪VP-1000进行踝臂脉搏波速度检测,收集研究对象的年龄、性别、身高等一般资料,采集空腹静脉血测量空腹血糖、甘油三脂、总胆固醇,询问研究对象合并存在高血压病、冠心病、糖尿病及脑卒中病史。根据踝臂脉搏波速度检测结果将研究对象分为踝臂脉搏波速度<1400cm/s组和踝臂脉搏波速度≥1400cm/s组,同时以踝臂脉搏波速度≥1400cm/s组作为动脉僵硬度增高的诊断标准。结果:新疆地区35～60岁汉族43.27%存在动脉僵硬度增加,45～50岁左右就开始出现,随年龄增加迅速进展,男性在40岁左右即开始出现动脉僵硬度增加,而女性在该阶段增加缓慢,但是50岁以后,女性动脉僵硬度迅速增加,与男性没有差别,总体情况下男性动脉僵硬度增加较女性明显。踝臂脉搏波速度<1400cm/s组与踝臂脉搏波速度≥1400cm/s组比较,年龄、性别、体重等一般资料在两组间有统计学差异(P<0.05),身高在两组间无统计学差异(P>0.05);甘油三酯、总胆固醇、低密度脂蛋白等生化指标在两组间有统计学差异(P<0.05),空腹血糖、高密度脂蛋白在两组间无统计学差异(P>0.05);合并存在高血压病、冠心病、糖尿病、脑卒中其中一种或任一两种组合的比率在两组间有统计学差异(P<0.05)。二元logistic回归显示,年龄(OR:1.307,95%CI:1.159～1.475,P<0.05),收缩压(OR:2.029,95%CI:1.732～2.377,P<0.05),舒张压(OR:1.548,95%CI:1.275～1.880,P<0.05),总胆固醇(OR:1.295,95%CI:1.104～1.518,P<0.05)。结论:新疆地区35～60岁汉族动脉僵硬度增加较为流行。动脉僵硬度增加与高血压病、冠心病、糖尿病、脑卒中等心血管疾病危险因素存在相关性。年龄、收缩压、舒张压、总胆固醇是新疆地区35～60岁汉族baPWV的危险因素,与传统心血管疾病危险因素一致。更多还原

【Abstract】 Objective: To investigate the prevalence of arterial stiffness and study the risk factors for the ankle-brachial pulse wave velocity in Xingjiang community in han (baPWV) . Methods: To test the baPWV from the crowd who live around Urumqi, Kelamayi, Yili by arterial stiffness early detection equipment VP-1000 made in Colin company of Japan, collected age, gender, body height and other general data, to measure fasting blood glucose, triglyceride, total cholesterol by collecting venous blood, to gather complicated disease like hypertensive disease, coronary heart disease, diabetes mellitus and stroke. Divided subjects into baPWV<1400cm/s group and baPWV≥1400cm/s group, and to consider baPWV≥1400cm/s as the arterial stiffness increased.Results: 43.27% of Xingjiang community in han at the age 35～60 exsit arterial stiffness increasd, generally before the age of 50, it is increasing with age, at the age of 40 the arterial stiffness increased in men, and in women this is slowly in this period, but at the age of 50 the arterial stiffness also increased in women, and have no difference with men, the arterial stiffness increased is more serious in men than women. Compared baPWV<1400cm/s group with baPWV≥1400cm/s group, age, gender, body weight and other general data exsited statistic significance(P<0.05), body height didn’t exsited statistic significance(P>0.05); triglyceride, total cholesterol, low density lipoprotein and other biochemical indicators exsited statistic significance(P<0.05), fasting blood glucose, high density lipoprotein didn’t exsited statistic significance(P > 0.05). Binary logistic regression showed that age(OR: 1.307,95%CI: 1.159～1.475, P<0.05), systolic blood pressure(OR: 2.029,95%CI: 1.732～2.377, P<0.05), diastolic blood pressure(OR: 1.548,95%CI: 1.275～1.880, P<0.05), total cholesterol(OR: 1.295,95%CI: 1.104～1.518, P<0.05).Conclusions: The prevalence of increased arterial stiffness is high in Xingjiang community in han at the age of 35～60 years. Increased arterial stiffness correlate with hypertensive disease, coronary heart disease, diabetes mellitus, stroke and other risk factors for cradiovascular diseases. Age, systolic blood pressure, diastolic blood pressure, total cholesterol are the risk factors for baPWV in Xingjiang community in han at the age of 35～60 years, the same as the traditional risk factors for cradiovascular diseases.更多还原