【作者】 高云飞；

【导师】 张国庆；

【作者基本信息】 新疆医科大学 ， 肿瘤学， 2009， 硕士

【摘要】 目的:观察125I粒子瘤内植入治疗晚期肺癌的近期疗效,探讨该方法治疗肺癌的临床价值。方法:对22例经病理证实的原发IIIB及IV期非小细胞肺癌患者,CT定位下行肺内病灶放射性粒子植入术。术后1~6个月进行临床随访,术后第2、3个月后全部行CT复查。结果:1、KPS评分:提高7例,稳定14例,下降1例。2、根据肺癌近期有效率的评定标准,125I粒子瘤内植入有效率(CR+PR)为73.9%(17/23)。3、肿瘤在5cm以下者有效控制率为93.3%,≤3者有效控制率为100%。4、所有病例未出现放射性肺炎、粒子丢失等严重并发症。结论:1、CT导向经皮穿刺瘤内植入125I粒子对晚期肺癌有较好的近期治疗效果,该方法能够提高患者的KPS评分(P<0.05)能够有效缩小肿瘤体积(P<0.05)。2、肿瘤大小与疗效有关,肿瘤越小,局部控制率越高。3、肺癌125I粒子瘤内植入治疗仍是一种局部治疗方法,有其局限性,对减少肿瘤远处转移的作用及远期疗效有待进一步研究。更多还原

【Abstract】 Objective: The purpose of this study is to investigate the short-term efficacy and explore the clinical value of 125I radioactive seeds implantation for treatment of advanced non-small cell lung cancer. methods: 22 cases of primary advanced non-small cell lung cancer (ⅢB andⅣstage) patients approved by pathology, and the 125I radioactive seeds implanted in their tumors in lung by CT-guided all. There is a 1 ~ 6 month clinical follow-up after operation regularly and reviewed by CT twice after two and three month all. Result:1. The evaluation of KPS as follows: 7 cases improved and 14 are stable, only one descend. 2.The effective rate (CR+PR) is 73.9%(17/23).3. The effective control rate of lesions less than 5cm is 93.3%, and lesions not more than 3cm is 100%. Conclusion:1.Therapy of the implanting 125I seeds guided by CT for pulmonary carcinoma presents a better clinical short-term therapeutic efficacy to the advanced non-small cell lung cancer, this method could improve the Karnofsky score and. reduce the tumor’s volume effectively. 2.The size of lesion is related to the therapeutic efficacy, the smaller lesion is,the better therapeutic efficacy is. 3. The implant of 125I seeds is just a local therapy, whether or not to decrease the incidence of distant metastasis and improve prospective efficacy is not yet assessed.更多还原