【作者】 王顺；

【导师】 桑晓红；

【作者基本信息】 新疆医科大学 ， 内科学， 2009， 硕士

【摘要】 目的:研究牙周炎与慢性肾功能不全的相关性。方法:对新疆和田墨玉县所属15个乡进行分层随机抽样调查,抽取3个乡,每个乡有5个村,每个村随机抽取110人,共抽取1650人,其中22人全口无牙不列入本次分析中, 122人未参加口腔检查,其余调查资料完整者1415人纳入本次研究。慢性肾功能不全的诊断标准为GFR<60ml/min/1.73m2。牙周炎的诊断由口腔专科医师完成,依据检查结果将1415名研究对象分为正常组/牙龈炎组、轻度牙周炎组、中度牙周炎组和重度牙周炎组。对调查资料进行卡方检验、多组秩和检验和Spearman等级相关分析。结果:1415人中有935人患牙周炎,占1415人中66.08%;慢性肾功能不全的有19人,占1415人中1.34%。牙周炎组和健康组相比,年龄、性别、血压、血脂、血糖有显著差异。秩和检验结果示:H=18.304,P=0.000。提示四组间差异有显著性意义,可认为不同牙周炎组慢性肾功能不全的患病情况有显著差异,根据平均秩次进一步推断,以重度牙周炎组的差异最为明显,平均秩次=714.55。Spearman相关分析结果:r_S=0.211,P=0。提示牙周炎的严重程度与GFR的下降呈显著正相关关系。结论:牙周炎尤其是重度牙周炎与慢性肾功能不全存在相关性,两种疾病之间相关性的本质仍需进一步明确。更多还原

【Abstract】 Objective: To study relationship between periodontitis and chronic renal insufficiency. Methods:We conducted a cross-sectional study of 1415 men and women in Moyu county He Tian city. Chronic renal insufficiency is defined as glomerular filtration rate(GFR) less than 60ml/min/1.73m Periodontitis was determined by using an independent clinically derived definition and categorized as health/gingivitis,initial,moder- ateand severe. Chi-square test, and Kruskal-Wallis H test of many groups and Spearman rank correlation analysis models were used to estimate the associations between chronic renal insufficiency and periodontitis. Results: A total of 935(66.08%) individuals had periodontitis. Nineteen(1.34%) individuals had a GFR less than 60ml/min/1.73m.Compar- ed with health/gingivitis, age, sex, blood pressure, blood lipid and blood glucose of periodontitis group were significantly different. Kruskal-Wallis H test showed: H = 18.304, P = 0.000. There was a significant difference among four periodontitis groups. Mean rank(714.55) further showed to severe periodontitis group was the most different. Periodontitis was associated with a GFR less than 60ml/min/1.73m~2(r_S=0.211,P=0). Conclusion: Periodontitis, especially severe periodontitis is associated with chronic renal insufficiency.A prospective study is necessary to determine the exact nature of the observed relationship.更多还原