【作者】 杨成雄；

【导师】 杨学东；

【作者基本信息】 天津大学 ， 生药学， 2008， 硕士

【摘要】 昌都锦鸡儿是豆科锦鸡儿属植物,灌木,主产于我国西藏、青海。昌都锦鸡儿长期以来作为藏药藏锦鸡儿的主要植物来源之一,藏文名为“佐木兴”,其根茎具有活血化瘀、降压、消炎散肿等功效,内用治疗高血压、多血症、月经不调,外用治疗跌打损伤等症。本课题开展了昌都锦鸡儿化学成分的研究,实验采用硅胶、凝胶、制备薄层等色谱方法对昌都锦鸡儿根茎的氯仿萃取部分进行了系统分离,得到18个单体化合物,通过紫外光谱、红外光谱、质谱、核磁共振、X-射线晶体衍射等手段鉴定了其中10个化合物的结构,分别为8个紫檀素:Homopterocarpin(Can-6), 3-Hydroxy-8,9-dimethoxypterocarpan(Can-10) 3-hydroxy-4,9-dimethoxypterocarpan(Can-11),4-methyoxy-maackiain(Can-12), Medicarpin(Can-13), Maackiain(Can-14), 3,4-dihydroxy-9-methoxypterocarpan(Can-15), 3,4-dih-ydroxy-8,9-methylenedioxypterocarpan(Can-16); 2个异黄酮:Olibergin A(Can-17),Cajanin(Can-18);其它化合物结构正在鉴定之中。其中Can-6, Can-10, Can-12,Can-15, Can-16, Can-17为锦鸡儿属植物中首次得到的化合物。首次发现了昌都锦鸡儿中紫檀素类成分成对存在的特殊现象,并从色谱和波谱性质对它们进行了初步的讨论。更多还原

【Abstract】 Caragana changduensis is a shrub of genus Caragana Fabra.,Leguminosae,mainly distributed in Tibet and Qinghai province. C. Changduensis of which Tibetanname is zuomuxing, has a profound medicinal history in Tibetan traditional medicine.Its rhizome has the efficacy of promoting blood flow, reducing blood pressure andeliminating inflammation, which can be treated with plethora, hypertension,catamenia disorder for internal use while bruises and contused wound for external use.Systematic isolation of chloroform extract of C. changduensis was carried out.Eighteen compounds were obtained by preparative chromatography methods of silicagel, Toyopearl, PTLC, et al. Based on UV, IR, MS, NMR and X-ray crystaldiffraction, ten of them were identified as fallows, 8 pterocarpans:Homopterocarpin(Can-6), 3-Hydroxy-8,9-dimethoxypterocarpan(Can-10) ,3-Hydrox-y-4,9-dimethoxypterocarpan (Can-11), 4-methyoxy-maackiain(Can-12), Medicarpin(Can-13), Maackiain(Can-14), 3,4-dihydroxy-9-methoxypterocarpan(Can-15), 3,4-di-hydroxy-8,9-methylenedioxypterocarpan(Can-16); 2 isoflavones: Olibergin A (Can-17), Cajanin(Can-18). The structures of the others are being identified. CompoundsCan-6, Can-10, Can-12, Can-15, Can-16, Can-17 are isolated from genus Caraganafor the first time. A special phenomenon of pterocarpan constituents existing in C.Changduensis have been discovered for the fist time. The chromatography andspectroscopy property of them have been discussed.更多还原