中药穿心莲的质量及应用研究

【作者】 杨琳；

【导师】 张振秋；

【作者基本信息】 辽宁中医药大学 ， 生药学， 2008， 硕士

【摘要】 本课题对常用中药穿心莲进行了质量研究和应用研究。在质量研究中采用薄层色谱法对中药穿心莲进行了鉴别研究;采用紫外-可见分光光度法测定中药穿心莲总内酯的含量;采用高效液相色谱法测定中药穿心莲中穿心莲内酯、脱水穿心莲内酯的含量,经方法学考察,其精密度、稳定性、重复性、回收率等均符合有关规定。同时,用波长切换法测定中药穿心莲中穿心莲内酯、脱水穿心莲内酯的含量并对中药穿心莲高效液相指纹图谱进行研究。在应用研究中对中药穿心莲进行工艺上的完善;同时,进行了穿心莲分散片成型工艺的研究,为穿心莲的临床应用、市场开发等提供坚实的实验基础。本课题通过对中药穿心莲质量及应用的研究,为中药穿心莲的开发、应用奠定了坚实的基础。更多还原

【Abstract】 The study has in the quality and applying research of commonly used Chinese pharmacy of Herba Andrographis.In the respect of the quality research,the Chinese pharmacy of Herba Andrographis were determined by TLC and which adopted the methods of UV solutions to determine the content of the total ester , which adopted the methods of the high performance liqiud chromatography to determine the norm ingredients of andrographolide and dehydroandrographolide.The accuracy,repeatability,stability and recovery of determining method all accord with the relevant regulation. Meanwhile we adopted the change of the wave to determine the norm ingredients of andrographolide and dehydroandrographolide and the Chinese pharmacy of Herba Andrographis were determined by the HPLC fingerprints.In the applying research, we make the preparing technique more suitable.Meanwhile we adopted the extractive which came from extraction artwork Tabellae Menispermi to investigat forming shaping artwork and quality criteria of dispersible tablet of Herba Andrographis which can provid consistence experimentation foundation for the clinical application and market exploitation.Through the research of this stutdy, we can control the quality of Herba Andrographis and provid the consistence foundation for the exploitation of Herba Andrographis.更多还原