大黄当归木香的不同配伍抑瘤作用的药效学研究

【作者】 汤宇；

【导师】 王文萍；

【作者基本信息】 辽宁中医药大学 ， 中西医结合临床， 2008， 硕士

【摘要】 目的观察大黄、当归、木香的不同配伍组合对Lewis肺癌、肉瘤-S180、艾氏腹水癌荷瘤小鼠抑瘤作用的影响,探讨大黄、当归、木香的最佳配伍关系。方法制备Lewis、肉瘤-S180、艾氏腹水癌荷瘤小鼠动物模型,随机分为模型组,大黄组,大黄当归组,大黄木香组,大黄当归木香组;通过测定荷瘤小鼠的瘤重、计算抑瘤率观察不同配伍组对肿瘤生长的影响。结果与模型组比较,大黄当归组对Lewis肺癌、肉瘤- S180、艾氏腹水癌抑瘤率分别达到78.52%、44.57%、64.95%。结论大黄当归组具有很好的抑瘤作用(P<0.05)。更多还原

【Abstract】 objective: By observing the anticancer effect of Rhubarb, Radix Angelicae, Radix Aucklandia mixed with different ratio on those Holland lump mouse vaccinated with Lewis lung cancer, sarcoma-S180, Ai-abdomen water cancer, the best ratio of those three Chinese medicine wasdiscussed.Methods: Build up the models for Holland lump mouse vaccinated with Lewis lung cancer, sarcoma-S180, Ai-abdomen water cancer, and divided in to several model groups for different medicine treatment using Rhubarb plus Radix Aucklandia, Rhubarb, Rhubarb plus Radix Angelicae, and Rhubarb plus Radix Angelicae and Radix Aucklandia, respectively. By measurement of the weight of tumors, calculate percentage of the anti-tumor effect for different medicine groups.Results: In comparison with the model group, the group of Rhubarb plus Radix Aucklandia has the anti-tumor effect of 78.52%、44.57%、64.95% for Lewis lung cancer, sarcoma-S180, Ai-abdomen water cancer, respectively。Conclusion :Rhubarb and Radix Aucklandia group have good anti-tumor effect (P < 0.05).更多还原