【作者】 王建波；

【导师】 路广晁；

【作者基本信息】 山东中医药大学 ， 中医内科学， 2008， 硕士

【摘要】 目的:观察蠲逆清中饮治疗脾胃湿热型反流性食管炎(reflux esophagitis, RE)的临床疗效,并从理论和临床研究两个方面探讨蠲逆清中饮治疗RE的机制。方法:临床选择符合纳入标准的RE患者60例,随机分为两组,治疗组(30例)给予蠲逆清中饮水煎剂,对照组(30例)给予胃力康颗粒(四川宝光药业股份有限公司生产),观察两组的临床疗效。结果:临床研究显示,治疗组治愈9例,显效16例,有效4例,愈显率(痊愈+显效率)为83.33%,总有效率为96.67%。对照组临床痊愈4例,显效4例,有效14例,愈显率为26.67%,总有效率为73.33%。治疗组胃镜疗效总有效率96.67%,对照组为73.33%。治疗组显著优于对照组(愈显率比较P<0.01,总有效率比较P<0.05,胃镜疗效总有效率比较P<0.05)。治疗组在胃镜疗效积分与中医证侯总积分和消除或改善泛酸、烧心、胸膈满闷、胸痛、纳差以及口苦口粘和嗳气等症状上,疗效优于对照组。结论:蠲逆清中饮是治疗脾胃湿热型RE的有效方剂,其机理可能与调节胃食管运动,改善食管下括约肌功能,以及对胃肠激素的调节和抗炎作用等有关。更多还原

【Abstract】 Objectiv:To observe the clinical curative effect of Juan Ni Qing Zhong Yin on reflux esophagitis of Damp Heat in Spleen and Stomach and explore the mechanism of which from theoretical and clinical aspects.Methods:60 cases with reflux esophagitis were divided into two groups at random:the treatment group (30 cases)and the control group (30cases).The former was given Juan Ni Qing Zhong Yin while the latter was given Wei Li Kang Ke Li.Symptoms and signs of each group were observed before and after the treatment,including gastroscope observing . Results:After one course of treatment,significant difference was apparent in the clinical effects;In the treatment group,9 cases recovered and 16 cases significantly improved,(thus the effectual rate is 83.33%),4 cases improved. The total effective rate in the treatment group is 96.67%.The effective rate of gastroscope observing was 96.67%.In the control group 4 cases recovered and 4 cases significantly improved,(thus the effectual rate is 26.67%),14 cases improved.The total effective rate in the control group is 73.33%. The effective rate of gastroscope observing was 73.33%.There were statistically significant differences in the total effective rate between the treatment group and control guoup(P<0.05).The effective rate from the treatment group is clearly superior. Conclusions:Juan Ni Qing Zhong Yin is an effective drug of treating reflux esophagitis of Damp Heat in Spleen and Stomach which Mechanism might have relations with accommodating gastrointestinal motility,improving the function of lower esophageal sphincter,Anti-virus and adjusting the hormone of stomach intestine.更多还原