【作者】 王雷；

【导师】 杜锡贤；

【作者基本信息】 山东中医药大学 ， 中医外科学， 2008， 硕士

【摘要】 目的:观察导师应用清热利湿饮治疗血热型银屑病的临床疗效,并通过研究银屑病患者心理健康水平及对患者治疗前后P物质(SP)、β-内啡肽(β-EP)含量检测,观察清热利湿饮对神经肽的影响,探讨精神因素在银屑病发病中的重要作用。方法:将60例血热型银屑病患者随机分成两组,各30例,I治疗组予以清热利湿饮,II对照组予以清热凉血饮,疗程12周,观察皮损分布范围、红斑严重程度、鳞屑多少、浸润程度及瘙痒程度等。采用ZUNG自我评定抑郁量表(SDS)、ZUNG自我焦虑量表(SAS)调查30例银屑病患者发病前精神状态。治疗组取20例进行治疗前后SP、β-EP含量检测,并与20例健康成年人作对照。观察治疗组治疗前后SP、β-EP含量的变化。结果:治疗组治愈率56.67%,总有效率93.33%;对照组治愈率30.00%,总有效率70.00%。两组相比有差异性(P<0.05),治疗组疗效优于对照组。银屑病患者总体倾向有轻、中、重度的抑郁和焦虑,抑郁和焦虑的患者分别占总数的66.67%和76.67%。治疗后SP、β-EP含量较疗前显著降低,疗前疗后比较差异有显著性(P<0.01)。结论:清热利湿饮治疗血热型银屑病疗效确切,其作用机理可能是与调节精神因素、抗病原微生物、抑制表皮细胞增殖、抗炎、调节免疫、调节代谢障碍等有关;心理因素在银屑病的发生中起了重要作用。更多还原

【Abstract】 Objective:To observe clinical efficacy of psoriasis of blood heat type patients treated with the Drink of Clearing Heat and Removing Damp by tutor. To observe the impact on neuropeptide by the Drink of Clearing Heat and Removing Damp through studying the mental and healthy level of psoriasis of blood heat type patients and the content of SP andβ-endorphin before and after treatment .To explore the effect on the occur of psoriasis by psychic factor. Method: 60 psoriasis of blood heat type patients were divided into two groups at random with the ratio of 1:1. Treatment group with the Drink of Clearing Heat and Removing Damp ,matched group with the drink of Clearing Heat and Cool The Blood. During 12 weeks’treatments,damage and distribution of skin, severity of erythema , quantity of dry scaly skin bits,degree of pruritus and soakage were observed.The psychic factors were studied with ZUNG Self-assess Depression Scale(SDS)and ZUNG Self-assess Anxiety Scale (SAS). We analysed changes of SP andβ-endorphin of 20 patients in treatment group before and after the treatment and was compared with 20 normal person’s.Results: Cure and obvious effect rate of The first group is 56.67% with total effect rate of 93.33%,Cure and obvious effect rate of The second group is 30.00% with total effect rate of 70.00%. there are difference between two groups(P<0.05).It was inclined to depression and anxiety of the mild and middling and severe degree in psoriatic patients. These were 66.67% and 76.67% respectively. After treatment ,the level of SP andβ-endorphin is decreased obviously, there are difference (P<0.01).Conclusion: Treating psoriasis of blood heat type with the clearing heat and removing damp has reliable efficacy and low recurrence rate. Adjusting psychosis and restrainting epidermal cell proliferation, anti-a inflammation effects,adjustments of immune and metabolical systems may act as its mechanisms.更多还原