【作者】 汪民；

【导师】 姚芳莲；

【作者基本信息】 天津大学 ， 材料学， 2007， 硕士

【摘要】 本论文制备了基于聚乳酸—聚乙二醇两亲性嵌段共聚物的胶束体系,并提出了能有效提高胶束稳定性的方法。首先以甲基丙烯酸和氯化亚砜为原料,合成了甲基丙烯酰氯(MAC)。通过MAC与聚乙二醇(PEG)的反应,得到了聚乙二醇单甲基丙烯酸酯(PEG-MMA)。在辛酸亚锡的引发作用下,将PEG-MMA和丙交酯进行聚合反应,合成出了聚乳酸—聚乙二醇单甲基丙烯酸酯(MMA-PEG-PLA)两嵌段共聚物。通过IR、1H-NMR、GPC和LC-MS等检测手段对其结构进行了表征。通过两亲性嵌段共聚物制备了MMA-PEG-PLA胶束水溶液。然后再在由过硫酸铵(APS)和四甲基乙二胺(TEMED)组成的氧化还原引发剂的作用下,向胶束水溶液中加入交联剂N-乙烯基吡咯烷酮(NVP),得到了交联反应后的PVP-PEG-PLA胶束。本实验对交联反应前后胶束的性质,如粒径大小、粒径分布、临界聚集浓度(CAC)和微观形貌等进行了分析和对比,并对所得胶束的稳定性进行了初步的探讨。最后以粉防己碱(TED)为模型药物,探讨了载药胶束在PBS缓冲液中的释放行为。更多还原

【Abstract】 This paper presented a new approach to improve the physical and chemical stability of biodegradable poly(ethylene glycol)-block-poly(lactic acid) (PEG-PLA) micelles. First of all, methacryloyl chloride (MAC) was synthesized by reacting methacrylic acid with thionyl chloride. Then, PEG monomethacrylate (PEG-MMA) was obtained through mono-terminated-group capping PEG with MAC. Initiating by stannous octoate, monomethacrylate-terminated PEG-PLA (MMA-PEG-PLA) was subsequently synthesized by polymerization reaction between PEG-MMA and lactide, which was prepared by catalyzing lactic acid with tin powder. Techniques like IR, 1H-NMR, GPC and LC-MS were utilized for characterization and measurement.MMA-PEG-PLA micelle was obtained based on amphiphilic diblock copolymer. Then, PVP-PEG-PLA micelle was prepared through adding crosslinking agent N-vinyl-2-pyrrolidone (NVP), which was catalyzed by a redox free-radical initiator composed of ammonium persulfate (APS) and tetramethylethylenediamine (TEMED). For the purpose of studying stability, characteristics such as particle diameter, polydispersity, critical association concentration (CAC) and morphology of micelles were monitored and compared before and after crosslinked reaction. Tetrandrine (TED) loaded micelles were as well prepared and their drug releasing behaviors were taken into consideration.更多还原