【作者】 张庚；

【导师】 刘东方；

【作者基本信息】 黑龙江中医药大学 ， 中西医结合临床， 2008， 硕士

【摘要】 目的:观察护心胶囊联合小剂量胺碘酮治疗房颤的临床疗效和安全性及对血浆心钠素水平的影响。方法:心房纤颤患者60例随机单盲分为对照组A组,治疗组B组,各组病例数均为30例,对照组给予胺碘酮口服,治疗组给与护心胶囊联合小剂量胺碘酮,治疗3月后观察房颤转复情况及血浆心钠素的变化。结果:1.两组用药3个月后转复疗效情况:治疗组显效率为80%,优于对照组为66%,治疗组总有效率93.3%亦高于对照组76.6%,差异显著(P＜0.05)。2.治疗组与对照组患者房颤发作时血浆心钠素治疗前无差别(P＞0.05);用药三月后,治疗组与对照组血浆心钠素水平相比较有显著差异(P＜0.05)。结论:1.护心胶囊是用于治疗心房纤颤恢复窦性心律的安全有效药物。2.护心胶囊联合小剂量胺碘酮治疗房颤疗效明显优于单纯应用胺碘酮。护心胶囊和小剂量胺碘酮有协同作用。3.护心胶囊联合小剂量胺碘酮能够降低心房纤颤患者血浆心钠素水平。更多还原

【Abstract】 Objective:To know the clinical therapeutic effects ,security and the influence on Atrialnatriuretic peptide made by using huxinjiaonang and low dose of amiodaronein the clinical study on treating patients with atrial fibrillation.Methods:60 patients with atrial fibrillation were divided into 2 group at random by the single blind method. Each group contains 30 cases. The control group took the amiodarone in the routine method;while the treatment group took both huxinjiaonao and low dose of amiodarone.The Course of treatment was 3 month.After the treatment I assayed the patients’ blood Atrial natriuretic peptide and recorded the condition of the atrial fibrillation changing into sinus rhythm,at last draw the conclusion.Results:(1)Three month after the treatment the effective rate of the treatment group was 80% ,while the control group was 66%,and the,well-healed rate on the treatment group was 93.3%,while the contol group was 76.6%, so the clinical effects of the treatment was better than that of the control group(P<0.05).(2) Before treatment the blood atrial natriuretic peptide in both groups when the atrial fibrillation emerged had no significant differences(P > 0.05),but three months after the treatment the blood atrial natriuretic in both groups decreased and the treatment group had much less atrial natriuretic peptide than the control group(P<0.05).Conclusion:(1)Huxinjiaonang was a safe remedy in treating the patients with atrial fibrillation.(2)Using Huxinjiaonang and low dose of amiodarone was better in treating the patients with atrial fibrillation than using amiodarone only. Huxinjiaonang and amiodarone had the effects of synergism. (3)Huxingjiaonang can discrease the blood atrial natriuretic peptide of thepatients with atrial fibrillation.更多还原