【作者】 齐会卿；

【导师】 王富军；

【作者基本信息】 河北医科大学 ， 内科学， 2008， 硕士

【摘要】 糖尿病足(diabetic foot,DF)的发生对患者个人、家庭和社会均造成了严重的经济、心理和医疗负担,目前这已成为一个全球性问题。DF是糖尿病性神经病变、血管病变和感染等多种因素共同作用的结果。其中,糖尿病性神经病变是DF发生的最重要因素;跖骨头下组织变薄、心理障碍可促进DF的发生;生长因子和蛋白酶表达和活性的变化延缓糖尿病足溃疡(diabetic foot ulcer,DFU)的愈合,这一发现为在分子水平治愈慢性难治性DFU提供了依据。临床处理时首先要明确其主要病因并进行相应的治疗;控制感染、局部减压和改善缺血是DF治疗的关键措施;高压氧、干细胞移植、生长因子和基质金属蛋白酶抑制剂的使用等为其治疗提供了更广阔的前景。DF重在预防,其关键在于识别高危患者并控制危险因素。更多还原

【Abstract】 Diabetic foot (DF) problems are common throughout the world, resulting in major economic, psychological and medical consequences for the patients, their families and society. DF results from the interaction of several contributory factors including diabetic neuropathy, peripheral vascular disease and infection , etc. Among these , neuropathy is the most important contributory cause in the pathway to DF. The reduction of subcutaneous tissue under the metatarsal heads and psychological dysfunction are associated with diabetic foot ulcer(DFU). Changes of their expression and activity of growth factors and proteases are relevant for the pathogenesis of the maintaining chronicity of DFU,which provides ways to correct the molecular defects that have reulted in its chronicity. The key measure to treat DFU is to control infection,to remedy ischemia and to relieve high foot pressure . Hyperbaric oxygen therapy , stem cell therapy , the use of growth factors and inhibitors of matrix-metalloproteinases supply us with a broader perspective.Early recognition and management of independent risk factors for DF are the basic key to prevent it.更多还原