【作者】 石珍亮；

【导师】 张逊； 徐美林；

【作者基本信息】 天津医科大学 ， 外科学， 2008， 硕士

【摘要】 目的1.探讨dsg3在非小细胞肺癌(NSCLC)和类癌中的表达情况以及其与患者年龄、性别、肿瘤大小、临床病理分期和肿瘤分化程度的关系;2.探讨dsg3的表达与NSCLC及类癌预后之间的关系。方法1.对天津市胸科医院胸外科2002年1月-2004年8月期间手术治疗的肺癌患者进行电话回访,取得详细随访结果的为58例NSCLC和12例类癌患者,利用K-M法计算其3年、5年生存率,并对其临床和病理资料进行分析。2.应用免疫组化法检测58例NSCLC和12例类癌组织中Dsg3的表达水平和分部情况。3.分析Dsg3在肺癌各组织类型间表达的差异及其与患者性别、年龄、肿瘤大小、临床病理分期和肿瘤分化程度之间的关系。4.分析鳞癌、腺癌和类癌患者的术后生存时间与Dsg3表达的关系。结果1.本组患者的平均术后生存时间为37.24±18.46月。利用Kaplan-Meier法计算得3年、5年生存率分别为60.34%、43.75%。2.Dsg3表达阳性组3年、5年生存率高于表达阴性组患者(P＜0.01)。对58例NSCLC患者按dsg3的阴/阳性表达绘制了生存曲线,并通过Log-rang检验比较其结果有统计学意义(P＜0.01)。由于类癌组例数较少,未作生存率的检验,但通过t检验对其生存时间进行分析发现表达阴/阳性者生存时间在统计学有显著差异。3.Dsg3的表达与性别、年龄、肿瘤临床病理分期等特征没有相关性(P＞0.05)。4.Dsg3的表达与肿瘤的病理类型、分化程度有相关性(P＜0.05),分化程度高组阳性表达高于分化程度低组。结论1.Dsg3在肺癌组织中的表达与否可以作为肺癌预后的一个指标,阳性表达提示预后较好。2.Dsg3的表达与肿瘤组织的病理类型和癌细胞分化程度的高低有相关性。更多还原

【Abstract】 Objective1.To investigate the expression of dsg3 in non-small cell lung cancer and carcinoid,and to discuss the reference of dsg3 with the size,staging,differentiation of the tumor tissue and gender,age of the patient. 2.To investigate the relationship of dsg3 and the 3-year, 5-year survival rate of lung cancer, the survival time after surgery of SCC,AD carcinoid and the expression of dsg3.Methods1. To follow up the surgery patients of tianjin chest hospital between Jan,2002 and Aug,2004 by telephone.58 non-small cell lung cancer patients and 12 caricinoid patients were obtained as an outcome,and 3-year survival, 5-year survival was also obtained according Keplan-Meier. The cilinical and pathological datas were also given. 2. The expression condition of dsg3 was detected in the 58 NSCLC tissues and 12 carcinoid tissues by immunohistochemical method. 3. Analyze the expression difference of dsg3 in each kind of NSCLC,discussion the relationship of the cilinical characteristic (gender,age) of the patients and size, staging,differentiation of the tumors. 4.Analyze the reference of dsg3 and 3-year survival, 5-year survival of the patients .Analyze the survival time after surgery of SCC,AD carcinoid and the expression of dsg3.Results1.The average St was obtained as 37.24±18.46 months,and the 3-year survival ,5-year survival was 60.34% and 43.75% by Kaplan-Meier. 2. The negative or masculine of dsg3 is closely associated with the survival of the patients ,the negative ones have a short survival (P<0.01) .We drawed survival curve of the 58 NSCLC patients,and the survival refered much with the expression of dsg3 .The St of the carcinoid, SCC, AD,patients is considered to be difference by t test (P<0.01) . 3. The expression of dsg3 is not associated with the cilinical factorssuch as age,gender. 4. The experession of dsg3 has a close relationship with the differentiation of the tumors. The low degreedifferentiation ones are negative compared to the high degree ones.Conclusions:1. The negative or masculine expression of dsg3 is asociated with the prognosis of lung cancer, and negative expression mostly cue a poor pronosis. 2.The expression of dsg3 is refered to the differentiation of the tumors,this study disclose that the high degree differentiation ones have a better masculine expression.更多还原