【作者】 罗中伶；

【导师】 陈国平；

【作者基本信息】 中南大学 ， 眼科学， 2008， 硕士

【摘要】 目的:了解长沙地区事业机关单位45岁以上人群中年龄相关性黄斑变性(AMD)的患病率,并分析影响AMD的相关因素。方法:我们把长沙市事业机关单位按省级、市级、区级单位进行分层;采用随机数字表法,每一层按20%的比例共随机抽取57家单位;对纳入调查人群进行视力、外眼、角膜、晶体、眼底、血常规、肝肾功能、血脂全套以及身高、体重等项目检查;从中筛选出16个可疑影响因素进行非条件logistic单因素分析,再对单因素分析有统计学意义的影响因素进行非条件logistic多因素分析,并根据标准回归系确定各因素对AMD影响的大小。结果:共有3147人接受检查,受检率为97.8%;确诊为AMD的患者为214人,总检出率为6.8%;其中干性AMD为5.6%、湿性AMD为1.1%;45-50、50-55、55-60、60-65、65-70以及70岁以上者的患病率分别为2.4%、2.3%、5.9%、7.4%、7.6%、9.1%;男性AMD患病率为6.5%,女性为7.5%。对AMD影响有统计学意义的相关因素有6项,按对AMD影响的重要性由大到小依次为年龄、总胆固醇、平均RBC体积、荤素习惯、红细胞压积(HCT)和文化程度。结论:1.长沙地区事业机关单位45岁以上人群中AMD的患病率为6.8%。2.AMD的患病率随着年龄增加而显剧增加;干性AMD患病率明显高于湿性AMD;性别差异无统计学意义。3.影响AMD有统计学意义的相关因素有6个。更多还原

【Abstract】 Objective:To investigate the prevalence of age-related macular degeneration in institution unity people age above 45 in Chang Sha.And analysis of correlation factor about age-related macular degeneration.Methods:We classify institutions unity of ChangSha city by provincial、municipal and district-leve units category.Each category being selected 20%,according to random number table,get 57 unities. 3218 persons age abover 45 are obtained from the above 57 unities.All the persons are carried out the examination of visual acuity、eyelid、cornea、lens、fundus、Blood-R、Liver and kidney function、lipid and Height weight、ets.We do non-conditional logistic single-factor analysis in 16 suspicious correlation factors being slected,and do non-conditional logistic multi-factor analysis among the above single-factor analysis with statistical significance,and then determine the important of each factor to AMD according to standard regression coefficient.Results:6.8%of included population had AMD and 5.6%of them were dry AMD and 1.1%wase exudative type.The prevalence of AMD in the age group of 45-50、50-55、55-60、60-65、65-70 and more than 70were identified as 2.4%、2.3%、5.9%、7.4%、7.6%and 9.1%.The prevalence of mal was 6.5%and 7.5%of female.Six correlation factors were statistically significant.According important to AMD from great to small were:age,total cholesterol,RBC average capacity,eating habit, packed red cell and culture degree.Conclusion:The prevalence of people working in institution unity age above 45 in Chang Sha was 6.8%;The prevalence of AMD is increased with aging,dry type higher than wet type,but not correlated with sex.Six correlation factors were statistically significant.更多还原