【作者】 曹味纯；

【导师】 李新国；

【作者基本信息】 中南大学 ， 妇科肿瘤， 2008， 硕士

【摘要】 目的:研究MK、VEGF—A在卵巢上皮性肿瘤组织中的表达,并探讨其临床意义。结果:MK在卵巢上皮性癌组织中为高表达,与卵巢上皮性良性肿瘤及卵巢交界性肿瘤之间有显著性差异(P＜0.01),且与肿瘤临床分期及淋巴结转移相关(P＜0.05),但与病理类型、及年龄均无相关性(P＞0.05)。VEGF—A高表达于卵巢上皮性癌组织中,与卵巢上皮性良性肿瘤及交界性肿瘤之间有显著性差异,并与肿瘤临床分期及淋巴结转移相关(P＜0.05),与病理类型及年龄无相关性(P＞0.05)。MK与VEGF-A在卵巢上皮性癌中表达具有一致性。结论:1.MK、VEGF—A的表达上调可能对卵巢上皮性肿瘤的发生发展中起重要作用。2.MK、VEGF—A与卵巢上皮性癌侵袭转移密切相关,其异常高表达可能成为卵巢上皮性癌的预后判断指标。3.在卵巢上皮性癌中,MK、VEGF—A两者之间的表达具有一致性,提示两者可能通过共同的途径参与卵巢上皮性癌的发生、发展及转移过程。更多还原

【Abstract】 Objective: To investigate the expression and clinical significances of midkine(MK)、vascular endothelial growth factor—A(VEGF—A) in epithelial ovarian tumors.Results: MK in epithelial ovarian cancer is higher in the expression, and benign tumors and ovarian tumor at the junction between a siginificant difference (P <0.01), and the clinical stage and tumor metastasis and related (P <0.05), But with the pathological type and age were not related (P> 0.05). VEGF-A high expression in epithelial ovarian cancer, and benign tumors and ovarian tumor at the junction between a significant difference, and clinical stages of tumor metastasis and related (P <0.05), and no pathological type and age Correlation (P> 0.05). MK and VEGF-A in epithelial ovarian cancer in the expression of consistency.Conclusion: (1)、MK, VEGF-A may increase the expression of epithelial ovarian tumors and development play an important role.(2)、MK, VEGF-A with epithelial ovarian cancer is closely related to the invasion and metastasis, the expression may become abnormal epithelial ovarian cancer prognostic indicators.(3)、Epithelial ovarian cancer, MK, VEGF-A between the expression of consistency, suggesting that the two may be the way through the common epithelial ovarian cancer to participate in the occurrence and development and transfer process.更多还原