【作者】 潘海兴；

【导师】 吴汉江；

【作者基本信息】 中南大学 ， 口腔临床医学， 2008， 硕士

【摘要】 目的:采用临床常用的体液免疫功能检测方法,观察口腔癌患者手术前后免疫球蛋白和补体浓度变化,初步探讨外科手术对口腔癌患者免疫系统的影响。方法:采用全自动特定蛋白分析仪定量测定了16例口腔癌患者手术前、手术后第3天及第10天外周血免疫球蛋白(IgG、IgA、IgM、IgE)、补体(C3和C4)浓度,比较不同临床分期,术前、术后不同时间段内口腔癌患者免疫球蛋白、补体浓度变化。结果:(1)口腔癌患者术前、术后第3天、术后第10天机体免疫球蛋白(IgG、IgA、IgM、IgE)和补体(C3和C4)浓度对于临床分期Ⅰ-Ⅱ期和Ⅲ-Ⅳ期相比均无显著性差别(P＞0.05);(2)口腔癌患者术前、术后第3天、术后第10天机体免疫球蛋白IgG、IgA、IgE和补体C4浓度相互比较均无显著性差别(P＞0.05);口腔癌患者术后第10天IgM浓度比术前、术后第3天明显升高(P＜0.05),口腔癌患者术前、术后第3天IgM浓度相互比较无显著性差别(P＞0.05);口腔癌患者术后第3天、第10天C3浓度分别和术前相比有明显升高(P＜0.05),口腔癌患者术后第3天和第10天C3浓度相比无显著性差别(P＞0.05);(3)口腔癌患者术前、术后第3天、术后第10天免疫球蛋白(IgG、IgA、IgM、IgE)和补体(C3和C4)浓度男女间相比均无显著性差别(P＞0.05)。结论:(1)不同临床分期的口腔癌患者机体免疫球蛋白(IgG、IgA、IgM、IgE)和补体(C3和C4)浓度无差别;(2)口腔癌患者术前术后机体免疫球蛋白(IgG、IgA、IgE)和补体C4浓度无变化;但是IgM、C3浓度有短暂升高,提示口腔癌联合根治术对患者术后免疫球蛋白和补体浓度变化影响有限;(3)采用临床常用的体液免疫功能检测方法评价口腔癌患者手术前后免疫球蛋白和补体浓度变化的意义有待进一步研究。更多还原

【Abstract】 Objectives: Clinical serum immune function commonly used detection method to observe immunoglobulin and complements for patients with oral cancer undergoing operation ,in the preliminary study on oral cancer surgery in patients with immune system effects.Methods: Peripheral blood was taken from 16 patients with oral cancer before operation and the third day and the tenth day after operation by automatic analysis machine of protein-specific quantitative detecting in immunoglobulin (IgG, IgA, IgM, IgE) and complements (C3 and C4) to compare the concentration in immunoglobulin and complements for patients with oral cancer of different clinical stages, different time period before and after operation .Results:(1) The concentration of immunoglobulin (IgG, IgA, IgM, IgE) and complements (C3 and C4) for patients with oral cancer before operation and the third day and the tenth day after operation between the clinical stage I-II and III-IV was no significant difference (P> 0.05).(2) The concentration of immunoglobulin(IgG, IgA, IgM, IgE) and complements (C3 and C4) for patients with oral cancer before operation and the third day and the tenth day after operation compared no significant difference (P> 0.05). The concentration of IgM of the tenth day after operation was than those of before operation and the third day after operation increased significantly (P <0.05), but between the concentration of IgM of before operation and the third day there was no significant difference (P > 0.05).The concentration of C3 of the third day and the tenth day after operation was than that of before operation increased significantly (P <0.05), but between the concentration of C3 of the third day and the tenth day after operation there was no significant difference (P > 0.05).(3) The concentration of immunoglobulin(IgG, IgA, IgM, IgE) and complements (C3 and C4) for patients with oral cancer before operation and the third day and the tenth day after operation between men and women there was no significant difference (P>0.05).Conclusion:(1) The concentration of immunoglobulin (IgG, IgA, IgM, IgE) and complements (C3 and C4)for patients with oral cancer in different clinical stages was non-discrimination.(2) The concentration of immunoglobulin (IgG, IgA, IgE) and complement (C3) for patients with oral cancer undergoing operation was non-discrimination, but the concentration of IgM, C3 was short-term increase, suggesting that the patients with oral cance after the radical surgery on the concentration of immunoglobulin and complements in a limited impact.(3) Clinical serum immune function commonly used detection method to observe immunoglobulin and complements for patients with oral cancer undergoing operation is to be studied further.更多还原