【作者】 边聪；

【导师】 郑杰；

【作者基本信息】 福建医科大学 ， 口腔临床医学， 2008， 硕士

【摘要】 目的:研究CN₀舌鳞癌病例中颈淋巴结隐匿性转移（PN₁）、隐匿性微转移(简称微转移,PN_m+)病例与确无淋巴结转移（PN₀）的病例三者间预后的关系,以确定PN_m+病例是否如PN₁病例一样需在术后补充放射治疗。方法:（1）搜集福建省肿瘤医院自1993年8月到2002年11月间的CNO舌鳞癌病例共54例。（2）对PN₀病例分别用免疫组织化学染色（IHC）和原位杂交（ISH）方法结合半连续切片查找PN_m+病例。（3）分别统计PN₁、PN_m+、以及PN₀组的死亡率及生存期。（4）对采集的数据用SPSS10.0软件进行统计学处理。结果:至研究结束时止,所有复发病例均已死亡,PN₁组与PN_m+组间的死亡率没有显著性差异;在PN₁组与PN₀组间以及PN_m+组与PN₀组间则存在显著性差异。PN₁组与PN_m+组的生存期没有显著性差异;在PN₁组与PN₀组以及PN_m+组与PN₀组间则存在显著性差异。结论:PN₁组与PN_m+组病例的预后相似,均较PN₀组例预后差,从而证明了PN_m+病例和PN₁病例一样,需要在手术后进行辅助放疗。更多还原

【Abstract】 Purpose: To investigate the relationship of the prognosis of the patients suffering tongue squamous cell carcinoma （SCC） with cervical lymph node occult metastasis（PN₁）, micro metastasis (PN_m+), none metastasis （PN₀）, in order to definite whether the patients with PN_m+ need postoperative radiotherapy as PN₁ .Methods: （1） Collect 54 cases of CN₀ tongue SCC treated in FuJian tumour hospital, ranged from Aug. 1993 to Dec. 2002. （2） All the paraffin block of PN₀ was restudied by immunohistochemistry stain （IHC） and in situ hybridization （ISH） with semi step section. （3） To add up the rate of death and the survival time. （4） All the data were analysesed with SPSS 10.0.Results: To the end of this study, all the patients with recurrence were dead. There is no significance in the ratio of death between the group PN₁ and PN_m+, and a significance between groupPN₁ and PN₀ as between the group PN m+1 and PN₀. There is no significance in survival time between group PN₁ and PN_m+,and a significance between the group PN₁ and PN₀ as between the group PN_m+ and PN₀.Conclusions: The prognosis of the patients with PN_m+.is equivalent with the patients with PN₁ . And they are poorer than the patients with PN₀. The patients with PN_m+ need postoperative adjuvant radiotherapy as the patients with PN₁ .更多还原