【作者】 潘俊；

【导师】 肖绍文；

【作者基本信息】 广西医科大学 ， 神经外科， 2008， 硕士

【摘要】 目的:观察颅内恶性胶质瘤术后替莫唑胺单纯化疗/联合放疗的临床疗效。方法:2007年3月至2008年3月入组合格患者35例,随机分成三组。一组为空白对照组,一组接受单纯化疗,一组接受化疗联合放疗。按照体表面积给于替莫唑胺胶囊化疗。放疗方法按常规分割60Gy/30次。同时每月进行临床随访,定期复查头颅强化CT或MRI与化疗前资料比较判断病情变化。以化疗后影像学及临床功能变化来评价治疗效果,并比较两种方案的治疗效果。结果:影像学检查提示化疗后3个月空白对照组和单纯化疗组的无进展生存率分别为14.29%、66.67%(P＜0.05),单纯化疗组和联合治疗组的有效率分别为16.67%、66.67%(P＜0.05);临床功能状态检查提示化疗后3个月功能改善率为41.67%。结论:应用替莫唑胺在颅内恶性胶质瘤术后进行化疗可延缓肿瘤的增殖和复发,改善临床功能,是减少该类疾病术后复发和提高术后生存质量的有效方法。化疗与放疗联合治疗效果优于单纯化疗。更多还原

【Abstract】 Objective:To observe the clinical effect of temozolomide in chemotherapy only/in radio-chemotherapy combined treatment for intracal glioblastoma after operation.Methods:From Spring 2007 to Spring 2008,35 eligile patients were randomised to divided in three groups.One group did not accept any therapy,one groups accept exclusively chemotherapy,one groups accept radio-chemotherapy combined treatment.TMZ was administered according to the body area. Radiotherapy project is routine dissection 60Gy/30 times.Meantime clinical experience should be performed every a month,and contrast enhanced CT scan or GD-MRI was performed to evaluate image-based progression comparing with the image before chemotherapy.We evaluate the therapeutic efficacy according to the imageology and clinical functional changes after chemotherapy. Results:3 month after chemotherapy.the progression to survival rate of the blanck control group and the chemotherapy group is separately 14.29%、66.67%(P＜0.05)according to the imageology.Meantime,the effective power of the exclusively chemotherapy group and the radio-chemotherapy group is separately 16.67%、66.67%(P＜0.05).the improvement rate of clinical functional status 41.67%。Conclusion:The chemotherapy application of temozolomide in Intracal spongioblastoma can delay the generation and recrudescence of tumor,it also can improve the clinical function.so it is an effective method of reducing the post-operation recrudescence and elevating the living quality The effect of radio-chemotherapy combined treatment is better than exclusively chemotherapy.更多还原