【作者】 吴妍；

【导师】 张爱珍；

【作者基本信息】 浙江大学 ， 内科学， 2008， 硕士

【摘要】 目的:研究糖尿病及糖尿病并发冠心病患者血脂、血糖及血栓形成指标水平的变化。方法:采用病例对照研究的方法对40例糖尿病、40例糖尿病并发冠心病及40例冠心病患者的血脂、糖化血红蛋白（HbA₁c）、糖尿病病程、体重指数（BMI）、血栓形成指标进行比较。结果:1.三组间,糖尿病并发冠心病组高密度脂蛋白-胆固醇（HDL-C）水平明显低于糖尿病组,D-二聚体水平明显高于糖尿病组（P＜0.05）。2.糖尿病组的BMI明显高于糖尿病并发冠心病组,但明显低于冠心病组（P＜0.05）。3.三组间,低密度脂蛋白-胆固醇（LDL-C）、纤维蛋白原（FBG）水平存在一定差异,但差异无显著性;糖尿病组和糖尿病并发冠心病组间HbA₁c和糖尿病病程存在一定差异,但差异无显著性。结论:糖尿病患者存在血脂代谢紊乱及血栓形成等危险因素,糖尿病患者、糖尿病并发冠心病患者与冠心病患者的血脂代谢紊乱、D-二聚体水平有所不同。更多还原

【Abstract】 Objective To investigate the changes of lipid level,serum glucose, thrombogenesis index of patients with diabetes mellitus and patients complicated with coronary artery disease.Method We compared lipid level,HbA₁c,the course of diabetes mellitus,BMI,D-dimer level of 40 patients with diabetes mellitus,40 patients with diabetes mellitus complicated with coronary artery disease and 40 patients with coronary artery disease by ease control study.Results 1.Among the three groups,the HDL-C level of group with diabetes mellitus complicated with coronary artery disease was significantly lower than that of group with diabetes mellitus（P＜0.05）,while D-dimer level was significantly higher than that of group with diabetes mellitus（P＜0.05）;The BMI of group with diabetes mellitus was significantly higher than that of group with diabetes mellitus complicated with coronary artery disease and significantly lower than the group with coronary artery disease（P＜0.05）. The LDL-C level and fibrinogen level of three group were no significant differences.The course and HbA₁c between group with diabetes mellitus and group with diabetes mellitus complicated coronary artery disease were no significant differences.Conclusion There are risk factors of lipid metabolic disorder and thrombogenesis etc.in patients with diabetes mellitus.Lipid metabolic disorder and D-dimer level of patients with diabetes mellitus,patients with diabetes mellitus complicated with coronary artery disease and patients with coronary artery disease are different.更多还原