姜黄的化学成分研究

【作者】 刘春艳；

【导师】 吴立军；

【作者基本信息】 沈阳药科大学 ， 天然药物化学， 2008， 硕士

【摘要】 姜黄为姜科姜黄属(Curcuma)多年生草本植物姜黄(Curcuma longa L.)的干燥根茎,全世界有50种,中国有16种,产于广西南部至东南部,具有破血行气止痛通经之功效,对姜黄药用有效成分进行提取分离和结构鉴定,有利于其药用资源的深层次开发,提高其药用价值。利用硅胶、ODS、凝胶柱色谱等分离方法对姜黄的95%乙醇(体积分数)提取物进行了化学成分分离鉴定,从中分离得到了14个化合物,通过理化性质以及波谱手段(NMR),鉴定了其中13个化合物的结构,分别为:姜黄素(curcumin,1)、β-谷甾醇(β-sitosterol,2)、琥珀酸(Butanedioic acid,3)、丁烯醛(crotonaldehyde,4)、1,7-dichlorol-isopropyl-4,7-dimethylperhydronaphthalene(isozingiberene dihydrochloride,5)、姜酮(Gingerdione,6)、3,3,5-三甲基-4-对甲基-苯基4-羟基-环己酮(3,3,5-trimethyl-4-(p-methyl)-phenyl-4-hydroxy-hextone,7)、双去甲氧基姜黄素(bisdemethoxycurcumin,8)、单去甲氧基姜黄素(demethoxycurcumin,9)、N,N-二甲基苯甲醛(4-(dimethylamino)-Benzaldehyde,10)、原儿茶酸(protocatechuic acid 11)、胡萝卜苷(daucosterol,12)、蔗糖(sucrose,13)。其中化合物5为一个新天然产物,化合物7为一个新化合物。更多还原

【Abstract】 The traditional Chinese medicine Curcuma longa is a member of the Ginger family.There are fifty kinds specices in the word,and only sixteen kinds were planted in China,mainly in Guang Xi province.It has been used in folk medicines as a toxinicide.For the purpose of finding much more bioactive agents from this plant and to supply its exploitation,the further chemical study of this plant was carried out.By mean of many kinds of isolation methods,such as Silica gel,Sephadex LH-20 and so on, the shade-dried roots of Curcuma longa(5 kg)were bladed and extracted with 95%ethanol and 14 compounds were isolated from this fraction.The structures of 13 compounds were identified by their physico-chemical characteristics and spectra data,and they were identified as curcumin(1),β-sitosterol(2),Butanedioic acid(3),crotonaldehyde(4), 1,7-dichlorol-isopropyl-4,7-dimethylperhydronaphthalene(isozingiberene dihydrochloride) (5),Gingerdione(6),(3,3,5-trimethyl-4-p-methyl-phenyl-4-hydroxyl-hextone,7), bisdemethoxycurcumin(8),demethoxycurcumin(9),(4-(dimethyla- mino)-Benzaldehyde (10),protocatechuic acid(11),daucosterol(12),sucrose(13)respectively.Among them compound 5 was a novel natural product,while compound 7 was a novel compound.更多还原