【作者】 帕丽达·阿布来提；

【导师】 古丽扎尔·买买提依明；

【作者基本信息】 新疆医科大学 ， 老年医学， 2008， 硕士

【摘要】 目的研究抑郁对中老年冠心病稳定性心绞痛患者白介素-1β(IL-1β)水平的影响。方法收集2007年7月至2007年12月期间住院治疗年龄≥50岁的中老年冠心病稳定性心绞痛患者86例。根据ZUNG抑郁自评量表(SDS)评定标准,冠心病伴抑郁患者62例(A组),冠心病不伴抑郁患者24例(B组),对两组患者的临床特征,血脂、血糖及IL-1β检测结果进行对比分析。结果两组研究对象在年龄、性别构成、吸烟、饮酒、受教育程度、合并高血压、合并糖尿病等之间的差异无统计学意义(P>0.05)。冠心病伴抑郁组IL-1β水平高于冠心病不伴抑郁组并且与不伴抑郁组比较有显著性差异,P<0.05。SDS问卷积分与IL-1β呈正相关,r为0.3013,P<0.01。同时按轻、中、重程度与IL-1β相关分析也呈正相关,r为0.3547,P<0.01。两组患者血脂水平无显著性差异,且与IL-1β之间没有相关性(P>0.05)。结论伴有抑郁的冠心病稳定性心绞痛患者血清IL-1β水平明显高于不伴有抑郁的冠心病患者,且与抑郁程度呈正比。研究表明抑郁与冠心病稳定性心绞痛之间通过免疫炎症因子这个中间因素影响冠心病的发生、发展、预后,是冠心病预后的预测因素之一。更多还原

【Abstract】 Objective To investigate the influence of depression on serum interleukin-1βlevel of middle age and elderly patients with coronary hear disease of stable angina pectoris. Methods Eighty-six (age≥50) middle aged and elderly (aging ) patients with coronary hear disease of stable angina pectoris who were admitted to our department from Augest2007 to December2007 recruited to our study. According to ZHUG questionnaire (SDS) score whether accompanied with depression or not 86 patients divided into two groups. There were 62 patients in Group A (patients with depression) and 24 patients in group B (patients without depression) respectively. We analyzed clinical data, serum lipid, blood glucose and interleukin-1βlevel of two groups. Results There was no significant difference between two groups when compare age, sex, smoking, drinking, education, accompany with hypertension, accompany with diabetic (P>0.05). The level of interleukin-1βin coronary hear disease accompany with depression higher than coronary hear disease without depression and significant different with without depression group, P<0.05. Correlation analysis results showed that SDS score was positive related to interleukin-1β, r was 0.3547, P<0.01. No significant different between two groups on lipid level and no related to interleukin-1B (P>0.05). Conclusion The level of interleukin-1βin coronary heart disease accompany with depression higher than coronary hear disease without depression and positive related to depression degrees. The study showed that depression through immune inflammatory cytokines effect to cause, developing, prognosis of coronary hear disease, it is one of the predictor factor of poor prognosis in coronary hear disease.更多还原