【作者】 孟柳；

【导师】 朱筠；

【作者基本信息】 新疆医科大学 ， 内科学， 2008， 硕士

【摘要】 目的:探讨2型糖尿病患者(T2DM)血清总抗氧化能力(TAOC)、血清丙二醛(MDA)、血清超氧化物歧化酶(SOD)水平与糖尿病周围神经病变(DPN)的相关性。方法:测定对照组52例及122例2型糖尿病患者血清总抗氧化能力(TAOC)及丙二醛(MDA),超氧化物歧化酶(SOD)水平;同时记录2型糖尿病患者的血压、身高、体重、血肌酐(Scr)、血尿酸(UA)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、甘油三酯(TG)、总胆固醇(TC)、纤维蛋白原(FIB)、空腹血糖(FPG)、糖化血红蛋白(HbA1c)、计算体重指数(BMI)。采用肌电图测定神经传导速度(NCV),神经电生理正常者为糖尿病非周围神经病变组(非DPN组)33例,神经电生理异常者为糖尿病周围神经病变组(DPN组)89例。采用SPSS11.5统计软件进行数据处理,所有计量资料用(均数±标准差)表示,进行t检验;计数资料进行χ2检验。以有无DPN为应变量进行多因素Logistic回归分析。两变量之间采用spearman秩相关分析。结果:对照组较2型糖尿病患者TAOC、SOD水平高,MDA水平低,有统计学差异(P<0.05),非DPN组与DPN组比较神经传导速度有统计学差异(P<0.05),非DPN组与DPN组比较体重指数(BMI)、收缩压(SBP)、舒张压(DBP)、空腹血糖(FPG)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、血肌酐(Scr)、血尿酸(UA),糖化血红蛋白(HbAIc )、超氧化物歧化酶(SOD)无统计学差异(P>0.05),而年龄、病程、FIB、TAOC、MDA在两组间有统计学差异(P<0.05),通过多因素Logistic回归分析:MDA、年龄、病程进入回归方程(P<0.05)。单因素分析中MDA与TAOC、SOD呈负相关,与病程、年龄及FIB呈正相关。结论:本组资料显示,随着年龄的增长、病程的延长、患者的MDA水平的增高与糖尿病周围神经病变的发生可能存在相关性。MDA可能参与了糖尿病周围神经病变的发生,氧化与抗氧化之间的失衡,可能是造成糖尿病周围神经病变发生的原因之一。此外,还应注意血液的高凝状态。更多还原

【Abstract】 Objective:To investigate of the correlation of Serum TAOC、MDA、SOD with T2DMdiabetic peripheral neuropathy。Method:serum level of the total antioxidant capacity (TAOC)and Malondialdehyde(MDA)and superoxide dismutase(SOD)were measured in 122 type 2 diabetes and in control group 52 subjects。meanwhile,Their blood pressure,body height, body weight,,serum creatinine(Scr), blood uric acid(UA), highdensity lipoprotein(HDL) ,lowdensity lipoprotein(LDL) ,triglyceride(TG),total cholestero(lTC), serum fibrinogen(FIB), Fasting blood glucos(eFPG)、glycosylated hemoglobin(HbAIc) were recorded; body mass index(BMI) were calculated。To use electromyogram to measure nerve conduction velocity( NCV )neuroelectricity electrophysiology normal is non- diabetic peripheral neuropathy(non-DPN)34 subjects;neuroelectricity electrophysiology abnormal is diabetic peripheral neuropathy(DPN)89 subjects。Statistics software SPSS11.5 was used for data processing. All the measurement data was expressed as (mean±standard deviation) and was analyzed by t-test; the numerical data was analyzed by Chi-square test. Logistic regression. was analyzed by means of with or without nodiabetic peripheral neuropathy as dependent variabelity.between two variables use to spearman rank correlation analysis. Results:control group serum level of the total antioxidant capacity (TAOC)and serum level of superoxide dismutase(SOD)is higher than diabetes group,serum level of Malondialdehyde(MDA)is lower than diabetes group。It has statistical significance between two groups(P<0.05)。nerve conduction velocity had statistical significance between two groups(P<0.05)。Body mass index,systolic blood pressure(SBP),diastolic blood pressure(DBP)、Fasting blood glucose、triglyceride、total cholesterol、highdensity lipoprotein、lowdensity lipoprotein、serum creatinine、blood uric acid、glycosylated hemoglobin、superoxide dismutase had no statistical significance between two groups(P>0.05)。as well as,age、duration of diabetes、TAOC、MDA、FIB had statistical significance between two groups(P<0.05),Analysis of Logistic regression showed that age、duration of diabetes and MDA level were the positive correlation factor of diabetic peripheral neuropathy(P<0.05)。MDA leval was correlated negative with TAOC、SOD;duration of diabetes、age、FIB was positive correlated with MDA。Conclusions:MDA level, age and duration of diabetescorrelated positively with diabetic peripheral neuropathy; MDA may participate in the development of type 2 diabetic peripheral neuropathy.Banlance disorder between with Oxidation and antioxygen may be one of the reasons diabetic peripheral neuropathy。Otherwise,we should be pay attention to hematic hypercoagulabale state.更多还原