【作者】 闫路平；

【导师】 王锋鹏；

【作者基本信息】 四川大学 ， 天然药物化学， 2007， 硕士

【摘要】 从弯距翠雀花(Delphinium campylocentrum Maxim．)全草提取物中分离得到13个单体化合物，并且用氢谱、碳谱、二维核磁共振谱、质谱、圆二色谱以及红外光谱对其中的11个化合物进行了鉴定，发现1个新的二萜化合物和2个新的去甲二萜生物碱，分别命名为弯翠平(campylopin)(1)以及弯翠生(campylocine)(2)和弯翠定(campylotine)(3)。其余8个已知生物碱是：delbrtmine (4)、talassimine(5)，talassamine(6)、talassimidine(7)，deltatsine(8)，delbonine(9)，dehydrodeltatsine (10)和delbruninemonoacetate(11)。弯翠平(1)为天然界中首次发现的具有hetidane型新骨架的二萜化合物。弯翠生(2)是天然界中首次发现的同时具有N-C(19)-O-C(1)氮杂缩醛和7，8-亚甲二氧基结构的牛扁碱型去甲二萜生物碱。化合物1的发现提示了一条新的海替定型二萜生物碱的生源途径假说。更多还原

【Abstract】 Thirteen compounds were isolated from the whole herb extract from Delphinium campylocentrum Maxim, and eleven of them were elucidated clearly based on the modem spectroscopic technologies including 1D- and 2D- NMR, MS, HRMS, CD, IR, etc. In such process, one novel hetidane-type diterpene skeleton, campylopin (1), and two new norditerpenoid alkaloids, campylocine (2) and campylotine (3), along with eight known alkaloids: delbrunine (4), talassimine (5), talassamine (6), talassimidine (7), deltatsine (8), delbonine (9), dehydrodeltatsine (10), and delbrunine monoacetate (11) were firstly discovered in this plant. The discovery of compound 1 implies a new biosynthetic pathway from the atisane or hetidane-type diterpene to the hetidine-type diterpenoid alkaloid.更多还原