【作者】 张玲玲；

【导师】 刘瑞芬；

【作者基本信息】 山东中医药大学 ， 中医妇科学， 2007， 硕士

【摘要】 目的:观察宫宁颗粒治疗瘀热互结型IUD出血副反应的临床疗效并探讨其作用机理。方法:1.临床研究共纳入患者119例,其中症属瘀热互结型IUD出血副反应患者99例(随机分为宫宁颗粒治疗组50例、消炎痛治疗组49例,均治疗1个疗程),无IUD避孕且月经正常的患者20例,为空白对照组。观察总体疗效、中医症候及子宫内膜组织学变化。2.动物实验将实验大鼠随机分为7组:假手术组、模型组、宫宁大剂量组、宫宁中剂量组、宫宁小剂量组、消炎痛组、空白对照组,每组8只。观察宫宁颗粒对大鼠子宫血管构筑变化的影响。结果:1.治疗组治疗瘀热互结型IUD出血副反应的总有效率为90.00%,对照组总有效率为71.42%,两组比较有显著性差异(p<0.05)。2.在中医症候改善方面上,宫宁组有效率为94.00%,消炎痛组为65.31%,两组比较有显著性差异(p<0.01)。3.在调经方面,宫宁组有效率为94%,消炎痛组为77.55%,两组比较有显著性差异(p<0.05)。4.宫宁颗粒可改善患者子宫内膜表浅微血管扩张,内皮细胞变性,基底膜不完整及管壁破裂,减少血栓形成,改善螺旋动脉扩张及平滑肌细胞排列紊乱。5.宫宁颗粒能明显改善置IUD大鼠子宫血管构筑的异常改变。结论:宫宁颗粒治疗瘀热互结型IUD出血副反应有显著疗效,对瘀热互结型IUD出血副反应患者子宫内膜血管损伤有保护和修复作用,能明显改善置IUD大鼠子宫血管构筑的异常改变。更多还原

【Abstract】 Objective:To investigate the clinical curative effect and mechanism of Gongning granules in treating patients with Endometrorrhagia caused by IUD-wearing diagnosed combination of stasis and heat syndrome. Methods:1.Clinical Study Bring into 119 cases of suffers altogether, 99 cases of them belong to combination of stasis and heat syndrome of Endometrorrhagia caused by IUD-wearing diagnosed (divided into Indomethacin treatment group with 49 cases of suffers and Gongning granules treatment group with 50 cases of suffers, both treated 1 course of treatment), 20 cases of them belong to blank comparison group without IUD contraception and menstruating normally. Observe total curative effect, herbalist doctor syndromes and endometrial histology changes. 2. The animal experiment All the rats for the experiment were divided into 7 groups:the pseudo-operative group,the IUD-insert model group,the high dose group of Gongning granules,the middle dose group of Gongning granules,the low dose group of Gongning granules,Indomethacin granules control group,the normal group , each group having 8 rats. Observe the influence of Gongning granules to the uterus vessel construct of the rats. Results:1.The rate of total curative effect which treatment group treated the patients with Endometrorrhagia caused by IUD-wearing diagnosed combination of stasis and heat syndrome was 90.00%,and the rate of total curative effect of the control group was 71.42%,the two groups were different(p<0.05). 2. In improving the TCM symptom ,The rate of effect which Gongning granules group was 94.00%,and the indomethacin group was 65.31%, the two groups were different(p<0.01). 3. In regualting menstruation, The rate of effect which Gongning granules group was 94.00%,and the indomethacin group was 77.55%, the two groups were different(p<0.05). 4.Gongning granules could improve superficial capillary vessel anapetia of Endometria, endothelial cell degeneration, basal membrane unintegrity and vessel wall disrupt,could decrease thromb, improve arteriae helicinae broaden and arrange derangement of contractile fiber cells. 5. Gongning Granules could obviously improve the abnormal transform of Endometrial angioarchitecture of IUD-wearing rats. Conclusion: Gongning Granules has great effect in treating Endometrorrhagia caused by IUD-wearing diagnosed combination of stasis and heat syndrome,can protect and restoring Endometrial blood vessel harm of Endometrorrhagia caused by IUD-wearing diagnosed , could obviously improve the abnormal transform of Endometrial angioarchitecture of IUD-wearing rats.更多还原