【作者】 鲍毅梅；

【导师】 宋晓平；

【作者基本信息】 新疆医科大学 ， 针灸学， 2007， 硕士

【摘要】 目的:建立与类风湿性关节炎(RA)病理变化基本相似的佐剂性关节炎(AA)大鼠模型,探讨天灸对佐剂性关节炎大鼠细胞免疫功能的影响。方法:建立与RA病理变化基本相似的佐剂性关节炎(AA)大鼠模型,随机分为空白对照组、模型组、模型+天灸命门组、模型+天灸关元组,实验观察:大鼠足跖与踝部的急性炎症性肿胀,继发的炎症表现;观测大鼠的跖厚;测定血清中IL-2含量;计算胸,脾指数。观察天灸单穴命门、关元穴对关节炎症状的影响及免疫作用。结果:(1)对趾厚及关节炎指数的影响:天灸两穴均可减小跖厚,减轻多发性关节炎和耳尾部炎性结节,降低关节炎指数;但两治疗组之间及与模型组比较,对趾厚的减轻差异不明显。(2)对于IL-2:两穴均可降低IL-2;(3)对胸、脾指数:天灸两穴均可提高胸指数,降低脾指数,但两组之间差异无统计学意义;(4)在对关节炎指数、IL-2的影响中,天灸关元、命门穴组间差异有统计学意义,天灸关元穴优于天灸命门穴组(P＜0.05～0.0083)。结论:天灸单穴命门、关元能提高AA大鼠IL-2水平,改善胸腺萎缩和脾脏肿大,对胸腺、脾脏起到了细胞保护作用,有类似抗原的免疫作用,能恢复和促进脾淋巴细胞活性,诱生和促进IL-2的分泌,具有正向的免疫调节作用。天灸对AA大鼠具有较好的疗效。更多还原

【Abstract】 Objective:To explore the influence of Medicinal Vesiculation the Cellular Immunity in Adjuvant Arthritis Rats through making Rats model of adjuvant arthritis(AA)that are similar with the RA.Methods:Rats model of adjuvant arthritis(AA)were made and randomized into control group,model group,model and medicinal Vesiculation the acupoints Ming Men group,model and medicinal Vesiculation the acupoints Guan Yuan group.The inhibitory effects on acute paw edema were observed and the paw thick and the levels of serum IL-2 levels were determined in experimental rats.account the big rats Spleen,the thymus gland index number.To explore the influence of the acupoints Ming Men group,and the acupoints Guan Yuan Medicinal Vesiculation the Cellular Immunity in Adjuvant Arthritis Rats.Results:(1)Medicinal Vesiculation has inhibitory effects on acute paw edema and the paws thick compared with model group,But the differences between the two Vesiculation groups and between the model group have not significant factors.(2)The activities of IL-2 in the serum were significantly raised(3)The big rat the thymus gland index number were significantly raised.The big rat’s Spleen index number was significantly decreased.But the differences between the two Vesiculation groups have not significant factors.(4)The guan Yuan are better than the Min Men group in the affection of IL-2 and the arthritis index number.The differences have significant factors(P＜0.05-0.0083).Conclusion: As far as the paws thick and the arthritis index number are concerned,medicinal Vesiculation of the acupoints Ming Men group,and the acupoints Guan Yuan have inhibitory effects on acute paw edema.It may raise the activities of IL-2 in the serum and the big rat’s thymus gland index number and decrease the big rat’s Spleen index number in order to protect the thymus gland and the Spleen.Moxibustion can improve the action of splenic lymphocyte activity.It has the same action as the antigenic immunifaction.Medicinal Vesiculation can obviously enhance and lure the secrete of IL-2 in the treatment of AA,moxibustion have positive immunoregulation affection in AA rats.Medicinal Vesiculation has significant affection to the Rats model of adjuvant arthritis(AA).更多还原