【作者】 王辉；

【导师】 多兰·达力汗；

【作者基本信息】 新疆医科大学 ， 皮肤病与性病学， 2007， 硕士

【摘要】 目的:探讨分析泛发性脓疱型银屑病的诱发或加重因素、临床表现、各种相关的实验室检查以及五种不同的治疗方法。方法:通过收集了1993年～2006年我科收治的33例泛发性脓疱型银屑病患者的病例,回顾分析了泛发性脓疱型银屑的多种诱发或加重因素及各种诱因或加重因素所占的比例,临床表现尤其是所伴发的全身症状的不同表现,各种实验室相关检查及五种不同的治疗方案的对比。结果:本组33例泛发性脓疱型银屑病病例中,找不到诱发或加重因素的居多,其余多种诱发或加重因素中最常见的为感染及皮质类固醇的使用不当。临床表现除典型的针尖至粟粒大小的无菌性脓疱的皮损外,常伴有多种全身症状的表现,其中以发热最为常见。各项相关的实验室检查中以血常规中的白细胞及中性粒细胞的升高、红细胞及血红蛋白的下降、低白蛋白血症、低钙血症最为常见。五种治疗方法的选用应根据患者病情轻重而选择不同的治疗方法。结论:泛发性脓疱型银屑病诱发或加重因素多种,临床表现除典型皮损外多伴有全身症状,有多种实验室检查的异常,根据患者病情轻重选择不同的治疗方法,糖皮质激素慎用。更多还原

【Abstract】 Objective: To discuss and analyse generalized pustular psoriasis patients’ causitive factors, clinical manifestations, some relative laboratory examinations and five kind of different treatments. Methods: Through collecting 33 cases of generalized pustular psoriasis patients who lived in my dermatological department from 1993 to 2006, retrospective analysis of generalized pustular psoriasis’ variable causitive factors and their percents, clinical manifestations, especially accompanied with systemic symptoms, some relative laboratory examinations and the comparation of five kind of different treatments. Results: In our patients, the most of them have no causitive factor, except for it, the inflammation and the improper use of corticosteriod are very common. In clinical manifest -ations, except for characteristic clinical manifestations that are aseptic pustulars from pinpoint to millet, it is frequently accompanied with systemic symptoms, espicially fever. In the relative laboratory examinations, the increase of leucocyte and neutrophils, the decrease of red blood cell, albumin and calcium is the most common. Five kind of treatments should be selected according to the severity of disease. Conclusions: Causitive factors of generalized pustular psoriasis are variable; its systemic symptoms are very common, except for its characteristic eruption; its results of several kind of laboratory examinations are abnormal; its treatments should be choosed according to the severity of disease, the use of corticosteriod should be cautious.更多还原