【作者】 郑超；

【导师】 包永星；

【作者基本信息】 新疆医科大学 ， 肿瘤医学， 2007， 硕士

【摘要】 目的:探讨影响喉癌患者生存率的相关因素。方法:回顾性分析77例喉癌患者的临床资料,包括年龄、性别、吸烟、族别、肿瘤部位、病理学分级、T分期、N分期、临床分期和治疗方式。应用Kaplan-Mei-er进行生存分析,组间比较用log rank检验,多因素分析采用Cox比例风险模型。结果:总的1年、3年、5年生存率分别为98.7%、73.4%、54.1%。单因素分析提示肿瘤部位、病理学分级、T分期、N分期、临床分期、治疗方式均有统计学意义(P＜0.05);多因素分析发现肿瘤部位(P＜0.046)、病理学分级(P＜0.027)、临床分期(P＜0.030)、治疗方式(P＜0.009)对预后的影响有统计学意义。结论:影响喉癌预后的因素为肿瘤部位、病理学分级、T分期、N分期、临床分期、治疗方式;其中独立预后因素为肿瘤部位、病理学分级、临床分期、治疗方式。更多还原

【Abstract】 Purpose:To investigate the factors affecting the survival rate of laryngeal carcinoma.Methods:Seventy-seven cases were analyzed retrospectively,including sex, age smoking,race,primary site.pathological grade,T-stage,N-stage,clinical stage, treatment methods.Survival analysis was performed by Kaplan-Meier method; comparison among/between groups was performed using log rank test;multivariate analysis was carried out using Cox proportional hazard model.Results:Overall 1-,3-and 5- year survival rates were 98.7%,73.4%and 54.1%.Univariate analysis showed that primary site,pathological grade,T-stage,N-stage,clinical stage and treatment methods were proven to significant(P＜0.05).Multivariate analysis showed the prognosis statistically correlated with primary site(P＜0.046),pathological grade(P＜0.027),clinical stage(P＜0.030)and treatment methods(P＜0.009).Conclusion:The factors affecting the prognosis of the patients with laryngeal carcinoma are primary site,pathological type, T-stage,N-stage,clinical stage and treatment methods;the independent prognostic factors are primary site,pathological type,clinical stage and treatment methods.更多还原