老年肺癌患者血清和尿液中碱性成纤维细胞生长因子的检测及意义

【作者】 刘振丽；

【导师】 王凤玲； 鲍文华； 闫红娥；

【作者基本信息】 佳木斯大学 ， 内科学， 2007， 硕士

【摘要】 本研究采用酶联免疫吸附法检测了30例老年肺癌患者血清和尿液中碱性成纤维细胞生长因子(basic fibroblast growth factor,bFGF)的表达及含量情况,研究老年肺癌患者血清和尿液中bFGF的表达及二者的相关关系、它们与肺癌的分化程度、临床分期等的关系。结果表明:1、肺癌患者血清中bFGF的浓度高于对照组(p<0.05),并与肺癌的恶性程度、分期相关。2、肺癌患者尿液中bFGF的浓度高于对照组(p<0.05),且与肺癌的恶性程度、分期相关。3、肺癌患者血清bFGF值与尿液bFGF值的关系通过Spearman等级相关分析,发现两者存在正相关(rs=0.9971,P<0.01)。结论:1、老年肺癌患者血清和尿液中的bFGF的水平明显增高。2、老年肺癌患者血清和尿液中的bFGF的水平与肺癌侵袭性、临床分期、不良预后等有密切关系,它们的检测可作为指导临床治疗的有价值的指标。3、老年肺癌患者血清和尿液中bFGF呈正相关,尿液bFGF水平可以反映血中bFGF水平,尿液bFGF有望成为老年肺癌患者的一项无创检查指标。更多还原

【Abstract】 In the study we evaluated the expression and the concentrations of basic fibroblast growth factor (bFGF) in the serum and urine. ELISA was used to detect the concentration of bFGF in the serum and urine of 30 lung cancer patients and the relationship between them ,then explore their relationship with the degree of tumor differentiation, clinical stage of lung cancer.The results demonstrated as below: 1、The concentrations of bFGF in the sera were higher in patients with lung cancer then those in the controls(p<0.05) ,and correlated with the clinical stages. 2、The concentrations of bFGF in the urine were also higher in patients with lung cancer then those in the controls (p<0.05),and correlated with the clinical stages. 3、The concentrations of bFGF in the urine and them in the sera were positive correlation.The following conclusions were drawd: 1、The concentrations of both serum and urinary bFGF are markedly high.2、Both serum and urinary bFGF are clinical relevant with lung cancer,they are correlated to the aggression and development of the lung cancer,the assay of serum and urinry bFGF is helpful in predicting the risk for metastasis and prognosis in lung cancer.3.、The serum and urinary bFGF were positive correlation.,urinary bFGF can reflex the concentrations of bFGF in the serum,and will be an atraumatic detection index for the elder lung cancer patients.更多还原