【作者】 邱玉超；

【导师】 李国明； 韦莉萍；

【作者基本信息】 华南师范大学 ， 高分子化学与物理， 2007， 硕士

【摘要】 本课题旨在合成一种纳米抗感染硅橡胶导尿管材料，该材料物理热力学性能优良，具有良好的抗菌性能，并能持续20多天的抗菌效果。采用无机蒙脱土（MMT）为原料，通过季铵盐有机改性，将具有亲水性的MMT改性成疏水性良好，并具有较大层间距的有机蒙脱土（OMMT）。同时对机械搅拌和超声波插层技术进行了初步的研究与探索，以获得具有不同层间距的有机改性钠基蒙脱土。XRD分析显示，全超声技术插层的OMMT层间距为2.51nm，而全机械插层的OMMT只有2.27nm。利用超声波技术，对钠基蒙脱土插层不同季铵盐进行有机改性。XRD分析表明，插层剂的烷基链越长，插层效果不一定越好。偏光显微镜观察可知，发现经过有机改性后，颗粒分散比较均匀。以自备的OMMT为载体，用丁胺卡那和Bardac^? 2280对其进行二次插层改性。通过正交实验设计，优化实验工艺得出合成Amikacin／OMMT的最优组合为反应温度60℃，投药比例(m_丁胺卡那：m_有机土)为1：4，反应时间3h，PH值为7.0；而Bardac^?2280／OMMT为反应温度50℃，投药比例(m_Bardac^?2280：m_有机土)为1：1，反应时间4h，PH值为4.0。XRD分析可知，经过药物二次插层后，衍射角减小，层间距增大，Bardac^?2280／OMMT比Amikacin／OMMT更明显；通过偏光显微镜可以看到，经过二次插层后，粒径减小了，其中Bardac^?2280／OMMT比Amikacin／OMMT更显著，分散更加均匀；抑菌环实验表明，Bardac^?2280／OMMT对大肠杆菌、金黄色葡萄球菌和白色念珠菌均有效，且效果明显；而Amikacin／OMMT只对前两者有效。利用插层复合法制备的纳米硅橡胶复合材料，在制备丁胺卡那—蒙脱土复合材料和Bardac^?2280—蒙脱土复合材料的基础上，用双辊混炼机分别制备了丁胺卡那—蒙脱土复合材料／硅橡胶片和Bardac^?2280—蒙脱土复合材料／硅橡胶片，并对制备的抗菌导管材料进行相关热学、力学性能和抗菌性能分析。DSC分析显示，粉体的加入，有利于硅橡胶在低温结晶，使得硅橡胶可以在更低的温度下使用；对于丁胺卡那—蒙脱土复合材料来说，7.5phr是最佳的比例，过量则使其结晶温度向高温移动；对于Bardac^?2280—蒙脱土复合材料来说，随着粉体含量的提高，结晶温度则一直往低温移动，但是考虑到力学性能因素，7.5phr含量较佳。力学性能测试表明，随着粉体的加入，胶料的各种力学性能增强，Bardac^?2280比丁胺卡那显著。偏光显微镜进行的表面分析表明：Bardac^?2280—蒙脱土复合材料比丁胺卡那—蒙脱土复合材料在硅橡胶载体中分散性更好，前者的相容性更好。药物缓释实验和抗菌性能实验分析表明：丁胺卡那—蒙脱土复合材料／硅橡胶具有较长的药物释放效果，但是Bardac^?2280—蒙脱土复合材料／硅橡胶性能更加优异，可以做理想的抗感染导尿管材料。更多还原

【Abstract】 The aim of this paper is synthesizing a kind of nano-antiinfectionsilicon rubber catheter material, which owns the characteristic of finephysical mechanics and good antiinfection properties. What’s more, suchmaterial can retain the effect of antiinfection for more than 20 days.Montmorillonite（MMT）, which possesses good hydrophilicity, wassynthesized with quaternary ammonium salt （QAS） modification intoorganic montmorillonite （OMMT）, a substance being hydrophobic andlarger in layer-distance. Meanwhile, a comparing study was done onmechanic stiring method and ultrosonic technology to get differentOMMT. X-ray diffraction （XRD） showed that the layer-distance ofOMMT through whole ultrosonic technology was 2.51nm while that bymechanic stiring method was only 2.27nm. Afterwards, OMMT was madewith QASs which had different chain length, followed by the result thatthe intercalating effect was not better though the chain length of QAS waslonger. Polarizing microscope indicated that the OMMT granule dispersedbetter after modification..A secondary intercalating modification was performed withAmikacin and Bardac（?）2280 based on OMMT to make Amikacin/MMTand Bardac（?）2280/MMT separately. The optimized synthesis technics ofcomposite materials was studied by morthogonal test. Consequently, theoptimized synthesis technics for Amikacin/MMT was as follows: reactiontemperature 60℃, ratio of casting stuff(m_Amikacin:m_OMMT) 1: 4, reaction time3h, PH 7.0; while that for Bardac（?）2280/MMT is 50℃, 1: 1, 4h and 4.0correspondingly. XRD showed that diffraction angle became smaller andlayer-distance got larger for these two kinds of composite materialsespecially for Bardac（?）2280/MMT. Polarizing microscope indicated thediameters for these granules minish and disperse even better, particularly for Bardac（?）2280/MMT. Bacteriostatis effect showed thatBardac（?）2280/OMMT had a better effect.Amikacin/OMMT rubber and Bardac（?）2280 catheters were preparedby intercalating compounding with a two-roll mixer. Afterwards, aserial of analysis was done on calorific, mechanical and antibacterialproperties. Differential scaning caloric （DSC） showed that siliconrubber could rime in a lower temperature, which made it could make intouse in such temperature; 7.5 percent was the best ratio forAmikacin/OMMT rubber and 7.5 percent for Bardac（?）2280 consideringmechanical property. The result showed that mechanical properties wereimproved as percentage of OMMT composites increased andBardac（?）2280 was more obvious than Amikacin/OMMT; meanwhile,Bardac（?）2280/OMMT dispersed better than Amikacin/OMMT inamong rubber; finally, drug releasing and antibacterial result showed thatAmikacin/OMM-rubber behaved well and Bardac（?）2280/OMMT-rubberwas much better therefore Bardac（?）2280 could be fully applied forsuch antibacterial catheters.更多还原